Instrumentation & Measurement Magazine 24-9 - 72

Fig. 2. (a) The TFBG-assisted SPR fiber-optic sensor and (b) its spectral responses for biomedical measurements; (c) The optical sensing system. (Adapted from [1]
and [3]).
In order to achieve high sensitivity and specific detection of
biological samples, the surface of the SPR optical fiber sensor
needs to be bio-functionalized, as shown in Fig. 3. Depending
on the species of biological molecules to be detected, specific
receptor molecules, such as immune response generators (antibodies,
antigens), enzymes, nucleic acids (DNA, RNA),
and cells are commonly selected to be adsorbed onto the surface
of the metal film. Antibodies possess reactive sites that
specifically recognize antigens. Antibody-antigen affinity induces
surface refractive index changes and all this process can
be detected in-situ as changes in the PR spectrum and recorded
by the interrogator using a single optical fiber. Combined with
micro-fluidic technology, as shown in Fig. 3, the detection
process can be precisely controlled with as little as microliter
volumes of bio-samples. Therefore, the TFBG-SPR sensor
is a good candidate for rapid and highly sensitive detection in
Fig. 3. The specific surface functionalization of a SPR optical fiber biosensor and its application combining in micro-fluidic chip technology.
72
IEEE Instrumentation & Measurement Magazine
December 2021

Instrumentation & Measurement Magazine 24-9

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