Charge and Current Measuring Electronics for Bio-Medical Applications Marco Carminati Read our Videos T he motion of electric charge is involved in several processes such as an electrochemical reaction taking place at a metal/electrolyte interface, the measurement of electrical impedance of a sample between a couple of electrodes or the absorption of a photon in a semiconductor and its conversion into an electron/hole pair (Fig. 1). Consequently, the quantification of the amount of charge collected at a sensing electrode is relevant in a broad variety of applications. This brief tutorial focuses on the challenges and techniques of measuring charge, primarily at the micro-scale, with application in the bio-medical field. Measurement Challenges The quality of a charge measurement is assessed mostly in terms of accuracy and resolution. Accuracy is the most relevant feature from the metrological point of view, and it is typically addressed by means of calibrations and control of polarizing effects and drifts, such as those due to temperature sensitivity. For example, gain and offset non-idealities of the acquisition chain (converting the input charge into a digital number and thus, being composed of both analog and digital blocks) are commonly corrected by simple linear equations. Non-linear errors can be corrected through extensive calibration and byhttps://ieee-ims.org/vt-program https://ieee-ims.org/vt-program