Journal of Oral Implantology October 2012 - (Page 575)

RESEARCH An Evaluation of Biocompatibility of Indigenously Produced Pure Titanium: An Experimental Study in Rabbits Bhogisetty Chittaranjan, MDS1* Late Bhamidipati Sreerama Murthy, MDS2 Turaga Ravindranath, MDS3 The indigenously produced pure titanium dental implants are economical and useful for common human use in India. The aim of this study is to test the biocompatibility of the indigenously produced pure titanium dental implant material obtained from the Defense Metallurgical Research Laboratory, Hyderabad, India, and the Institute of Nuclear Medicine and Allied Science, Delhi, India. An experimental study in rabbits was done to study the amount of ordered bone formation around the screw and cylinder type of indigenously produced pure titanium metal implant specimens. The experimental animals were killed at 4, 6, 8, 12, and 16 weeks from the date of implantation. The histopathological examination of the animals killed at 16 weeks demonstrates the presence of osteoblastic cell proliferation and early ordered bone formation toward the implant site, indicating signs of osseointegration of both screw- and cylinder-type indigenously produced pure titanium specimens. Key Words: indigenously produced pure titanium, biocompatibility, osseointegration INTRODUCTION n ideal prosthesis, besides having good retention, should have the other ideal requirements of biocompatibility, esthetics, phonetics, and masticatory function to achieve patient acceptance. Prosthesis without adequate retention creates problems to the patient and the dental professional. Improvements in metal technology led to an era of expanded surgical use of metallic implants.1 Pure titanium as an implant material is extremely well tolerated by the body tissues.2,3 Titanium and its alloys are important in dental and surgical implants because of their high degree of biocompatibility, strength, and corrosion resistance.4 Biocompatibility Department of Prosthodontics, ITS-CDSR, Muradnagar, India. Government Dental College, Hyderabad, India. Army Dental College, Secunderabad, India. * Corresponding author, e-mail: prosthoranjan@yahoo.com DOI: 10.1563/AAID-JOI-D-09-00099 2 3 1 A includes physical, mechanical, chemical, and electrical properties of the materials per se. All of the implant materials should be biologically inert without producing any host tissue reactions.5 The concept of osseointegration was developed and the term conceived by Dr Per Ingvar Branemark.2,6 Branemark’s experimental and clinical applications have been replicated in several centers and indicate an important advance in the field of tissue-integrated prostheses.7–11 The concept of osseointegration is based on research that began in 1952 with microscopic in situ of bone marrow in the fibula of rabbits.2 There are various reports4,12 about the use of titanium in its pure form or its alloys as implant materials. There are many reports13–15 to substantiate the soft-tissue biocompatibility of pure titanium. It has been demonstrated that the epithelial cells attach to the titanium surface in the same manner, as observed around the surface of natural teeth.16 There are reports regarding the nontoxic and noncarcinogenic nature of titanium implants.1 Many companies abroad are producing different Journal of Oral Implantology 575

Table of Contents for the Digital Edition of Journal of Oral Implantology October 2012

Should the Implant Fit the Patient or Should the Patient Fit the Implant?
Histologic and Biomechanical Evaluation of Alumina-Blasted/Acid-Etched and Resorbable Blasting Media Surfaces
Impact of Dental and Zygomatic Implants on Stress Distribution in Maxillary Defects: A 3-Dimensional Finite Element Analysis Study
Precision of Implant Placement With Stereolithographic Templates: A Pilot In Vitro Study
An Evaluation of Biocompatibility of Indigenously Produced Pure Titanium: An Experimental Study in Rabbits
Relationship Between Smoking and Bleeding on Probing
Stress Analysis in Platform-Switching Implants: A 3-Dimensional Finite Element Study
Acrylic Resin Polymerization in Direct Contact to the Abutment and the Temperature at Bone-Implant Interface: A Pilot In Vitro Study
Clinical Application of Stereolithographic Surgical Guide With a Handpiece Guidance Apparatus: A Case Report
Fixed Rehabilitation of Severely Atrophic Jaws Using Immediately Loaded Basal Disk Implants After In Situ Bone Activation
A Functional Open-Tray Impression Technique for Implant-Retained Overdenture Prostheses
Use of Plasma Rich in Growth Factor for Schneiderian Membrane Management During Maxillary Sinus Augmentation Procedure
A Technique to Facilitate the Fabrication of Provisional Restorations for ITI Solid Abutments
Influence of Etiologic Factors in Peri-Implantitis: Literature Review and Case Report
Simplistic Partially Limiting Surgical Guide for Flapless Implant Placement: A Case Report
Types of Implant Surgical Guides in Dentistry: A Review
Rehabilitation of Atrophic Posterior Maxilla With Zygomatic Implants: Review

Journal of Oral Implantology October 2012