Journal of Oral Implantology April 2013 - (Page 148)

RESEARCH The Clinical and Histologic Outcome of Dental Implant in Large Ridge Defect Regenerated With Alloplast: A Randomized Controlled Preclinical Trial David M. Kim, DDS, DMSc1* Marc L. Nevins, DMD, MMSc1 Zhao Lin, DDS, PhD1 Ardavan Fateh, DDS1 Soo-Woo Kim, DMD, MS, DMSc1 Peter Schupbach, PhD2 Myron Nevins, DDS1 A basic tenant of successful osseointegration is that the implant resides in a sufficient quality and quantity of bone to ensure bone contact and thus stabilization. A prospective, randomized controlled preclinical trial was conducted to evaluate the bone-to-implant contact (BIC) when placing implants in bone regenerated by 3 different combinations of biphasic calcium phosphate (BCP). Dental implants were placed into the regenerated ridges of 6 female foxhounds; the ridges were reconstructed with different formulations of BCP in combination with an hydroxyapatite collagen membrane. They were retrieved after 3 months to perform light microscopic and histomorphometric analyses. Implants in each group appeared to be stable and osseointegrated. Light microscopic evaluation revealed tight contacts between the implant threads with the surrounding bone for all 4 groups. The mean BIC ranged from 64.7% to 73.7%. This preclinical trial provided clinical and histologic evidence to support the efficacy of all 3 formulations of BCP to treat large alveolar ridge defects to receive osseointegrated dental implants. Key Words: canine, localized alveolar ridge defect, alloplast, biphasic calcium phosphate, hydroxyapatite collagen membrane, dental implants, bone-to-implant contact INTRODUCTION T he basic tenant of successful osseointegration is that the implant resides in a sufficient quality and quantity of bone to ensure bone contact and stabilization. Over the years, dental implants demonstrated a high success rate.1 Biphasic calcium phosphate (BCP) has been 1 Department of Oral Medicine, Infection and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Boston, Mass. 2 Schupbach Ltd, Service and Research for Histology, Microscopy and Imaging, Horgen, Switzerland. * Corresponding author, e-mail: dkim@hsdm.harvard.edu DOI: 10.1563/AAID-JOI-D-12-00242 148 Vol. XXXIX /No. Two / 2013 investigated extensively and has emerged as a promising bone substitute material.2–10 This grafting material consists of fully synthetic hydroxyapatite (HA) and beta-tricalcium phosphate (b-TCP), mixed at various ratios. The slowly resorbing HA acts as stable volume maintainer for bone regeneration, whereas the fast dissolution of b-TCP releases calcium and phosphorous ions that stimulate new bone formation. Several studies have shown that BCP is a biocompatible and effective bone replacement substitute in sinus augmentation, and implants placed in BCP grafted sites demonstrate a similar survival rate compared to other grafting materials.2,3,5,6 However, there are limited citations avail-

Table of Contents for the Digital Edition of Journal of Oral Implantology April 2013

Evidence-Based Practice or Practice-Based Evidence?
Evaluation of Optimal Taper of Immediately Loaded Wide-Diameter Implants: A Finite Element Analysis
A Prospective, Randomized Controlled Preclinical Trial to Evaluate Different Formulations of Biphasic Calcium Phosphate in Combination With a Hydroxyapatite Collagen Membrane to Reconstruct Deficient Alveolar Ridges
Retention of Implant-Supported Overdenture With Bar/Clip and Stud Attachment Designs
The Clinical and Histologic Outcome of Dental Implant in Large Ridge Defect Regenerated With Alloplast: A Randomized Controlled Preclinical Trial
Fluoride-Treated Bio-Resorbable Synthetic Hydroxyapatite Promotes Proliferation and Differentiation of Human Osteoblastic MG-63 Cells
Resonance Frequency Analysis of 208 Straumann Dental Implants During the Healing Period
A Simplified Technique for Solving the Transfer Problem of Implant-Supported Fixed Partial Dentures for Patients With Microstomia
Esthetic Evaluation of Single-Tooth Morse Taper Connection Implants Placed in Fresh Extraction Sockets or Healed Sites
A Technique for Improving the Retention of Dentures Retained by Ramus Frame Implants
Treatment of Congenitally Missing Maxillary Lateral Incisors: An Interdisciplinary Approach
Use of Titanium Mesh in Lieu of a Fixation Screw to Stabilize an Autogenous Block Graft: A Case Report
A Novel Approach to Preserve the Buccal Wall in Immediate Implant Cases: A Clinical Report
Implant Failure Associated With Actinomycosis in a Medically Compromised Patient
Replacement of Mandibular Posterior Teeth With Implants in a Postmandibular Resection Case: A Case Report
Zygomatic Implants/Fixture: A Systematic Review
An Overview of Immediate Root Analogue Zirconia Implants
Letter to the Editor
Reviews of Current Literature

Journal of Oral Implantology April 2013

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