The Catalyst Review June 2020 - 6

PROCESS NEWS
Sustainable Iron Catalysis Enables Controllable Alkene Borylation...
Boron-containing molecules are an attractive approach to access aliphatic organoboron compounds which involves catalytic
hydroboration or protoboration of carbon-carbon (C-C) double bonds. A modern variation of this process involves remote borylation,
whereby boron is inserted distant from the initial reactive site. However, existing methods often lead to borylations at the terminus
or at activated positions geminal (α) to functional units. Installing the coveted boryl group at unactivated positions is a formidable
challenge. A research team led by Prof Koh Ming Joo, from the Department of Chemistry, National University of Singapore (NUS)
has developed a new catalytic transformation
known as remote protoboration. In this system,
a single iron-based complex promotes alkene
isomerisation followed by site-selective protoboryl addition to the C=C bond. Thus, boron
can be installed at typically less-activated
positions vicinal (β) to common functional
groups. The protocol has significant scope and
utility in the synthesis of medicinally relevant
compounds. Prof Koh said, "This discovery
Schematic showing the design of remote protoboration to achieve selective borylation at less-activathas tremendous implications beyond remote
ed β positions.
protoboration. If we can precisely manipulate the
position of alkene shifts and subsequent proto-boryl insertion, we can potentially install boron at any desired location of an organic
molecule. The insights gained from our studies are expected to advance general efforts towards this ultimate goal," added Prof Koh.
The research team plans to apply the new concepts to address other challenges pertaining to site-selective functionalisations of
organic molecules for the synthesis of important compounds of interest. Source: National University of Singapore (NUS), 6/9/2020.
Industry Perspectives (continued from page 1)

With continuous worldwide research on FA as prospective LOHC candidate, the future seems to be promising in the realm of
carbon-neutral energy system, after addressing the most critical challenges related to the three P's (production, purity and price)
of FA, as well as the catalyst cost and durability.
References
International Energy Agency. (2015). World Energy Outlook.
Global Monitoring Laboratory. (2020). "Trends in Atmospheric Carbon Dioxide: Global Monthly Mean CO2."
https://www.esrl.noaa.gov/gmd/ccgg/trends/graph.html
FuelCellsWorks. (2020). "In 2019: 83 New Hydrogen Refuelling Stations Worldwide."
https://fuelcellsworks.com/news/in-2019-83-new-hydrogen-refuelling-stations-worldwide/
Eppinger J and Huang KW. (2017). "Formic Acid as a Hydrogen Energy Carrier." ACS Energy Lett. 2: 188-195.
https://doi.org/10.1021/acsenergylett.6b00574
Cursor. (2020). "Team FAST goes commercial as DENS."
https://www.cursor.tue.nl/en/news/2018/december/week-2/team-fast-goes-commercial-as-dens/
DENS. (2020). Dutch Energy Solution. https://dens.one/
About the Author
Dr. Joyanta Choudhury completed PhD in 2006 working on the development of well-defined Ir-Sn heterobimetalic
complexes for electrophilic aromatic functionalization reactions. After spending one more year in the Roy group as
a Research Associate, he moved to The Scripps Research Institute, Jupiter, Florida, to work with Prof. Roy A. Periana
in the field of transition-metal catalyzed C-H activation reactions. In 2008, Joyanta received the prestigious Marie
Curie International Incoming Fellowship from the European Union, and moved to the Weizmann Institute of Science,
Israel for his second postdoctoral stint with Prof. Milko E. van der Boom and worked in the fields of fundamental
organometallic chemistry and coordination-driven molecular assemblies on solid surfaces. In April of 2011, he accepted an offer
to join the Department of Chemistry, IISER Bhopal, as an Assistant Professor. From May 2017 he is Associate Professor in the
same department. His research interests include C-H activation-functionalization of alkanes and arenes to value-added chemicals,
mechanistic investigations of fundamental organometallic reactions (bond-activation, insertion, reductive elimination etc.),
organometallic materials for water oxidation and energy-related problems, molecular information processing and logic gates, and
coordination-driven molecular assemblies on solid surfaces. Joyanta can be reached at joyanta@iiserb.ac.in.
6

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https://www.esrl.noaa.gov/gmd/ccgg/trends/graph.html https://www.fuelcellsworks.com/news/in-2019-83-new-hydrogen-refuelling-stations-worldwide/ https://www.doi.org/10.1021/acsenergylett.6b00574 https://www.cursor.tue.nl/en/news/2018/december/week-2/team-fast-goes-commercial-as-dens/ https://www.dens.one/

The Catalyst Review June 2020

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