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« FORMULATION AND DEVELOPMENT
Figure 1. Transformation Map
and architecture principals of the consortium. After selection of
these vendors, the team quickly moved into proof-of-concept (POC)
implementations at four member companies.
Use Case: Integrated
Laboratory Notebook
Having decided to move forward, the next step was to define use cases
that explored the capabilities of emerging technology to transform
the laboratory. The Bristol Myers Squibb (BMS) team focused on a new
approach that combined wearable technology with a dynamic and
flexible electronic laboratory notebook (ELN).
The ELN is a core tool used in research and development, however
over the years its functionality and adaptability has not kept pace
with other software tools and platform integration capabilities that we
expect from our personal technology.
The use of wearables to collect experimental information logically
requires linking with an ELN. The use case was to enable mobile, handsfree
data capture via a real-time interface between headset wearable
technology from Apprentice.io and an interface to devices and
instrumentation with data platform in development by Varya Virtual
documenting laboratory activities, (Figure 2). Anticipated benefits
included a more immersive lab experience and learnings that would
drive knowledge gathering efficiencies with improved workflows and
consistent practices.
The Apprentice platform was already in place at BMS, utilizing a
RealWear HMT-1 headset and an iPad to capture a wide range of lab
activity information. This enables unencumbered procedure execution
with video and audio recording along with automatic data capture
using the Apprentice platform. Varya's platform, Iota, uses a Microsoft
Office 365 (MS365) framework and a combined Teams and OneNote
interface. The (MS365) platform is widely used within and beyond the
healthcare industry, providing a familiar workflow and interface (ref
3). The setup and integration of Varya's ELN was through a Microsoft
Teams portal hosted in a cloud environment and accessible via the
web-based Teams client. After 2-3 hours of hands-on introduction and
training, Varya's Iota became relatively easy to use based on previous
ELN platform experience and familiarity with MS365 applications. One
major concern encountered was that the desired real time interface
between the Apprentice and Varya platforms was not possible within
the time constraints of the POC, consequently indirect file uploads
were used instead.
The overall structure and linkage of the two vendor platforms
are shown in Figure 2. The evaluation by a handful of scientists
demonstrated that with a small amount of planning most activities
and data outputs of lab experiments could be easily captured in the
ELN. The key takeaways were as follows:
* Apprentice tools enabled lab experiment stepwise information
collection via video capture and dictation combined with
templates and real-time data base connections.
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APR January/February 2022

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