Dentaltown March 2022 - 19

The new study adds to the established evidence
for Aleve® for minor dental pain
In 2 previous clinical studies for dental pain, Aleve® was
proven to be stronger from the 3-hour mark onward and last
longer than acetaminophen plus codeine (APAP + codeine).
Both 8-hour studies (N=455) compared 1 dose of Aleve®
440 mg with 1 dose of APAP 600 mg + codeine 60 mg
after surgical removal of 3 or 4 molars (≥1 impacted).5,7
In both studies:
* Patients who took Aleve® reported significantly reduced pain
vs APAP + codeine (P<0.05) from the 3-hour mark onward5
* The 12-hour strength of Aleve® gave patients more
sustained pain relief per dose, as demonstrated by a
longer median time to remedication, vs patients on APAP +
codeine (P<0.05), which is commonly prescribed every
4 hours as needed2,5,7
* Study population for Study 1: Aleve® (n=92), APAP + codeine
(n=91), and placebo (n=47); and for Study 2: Aleve® (n=90),
APAP + codeine (n=91), and placebo (n=44)5
With the current opioid crisis, consider other options
for treating minor dental pain
The United States accounts for 80% of the global opioid
supply,8
and opioids kill over 130 Americans every day.9
Yet
despite available pain relief options, opioids associated with
dental treatment continue to pose significant risks to patients
and their family members.8,10
A recent study shows that opioids are not associated with
greater patient satisfaction for pain management after dental
extractions.11
" Recommend NSAIDs, like Aleve®, for non-opioid relief
of minor dental pain, and you can help address the
human and economic costs associated with the US
opioid crisis. " 1,4,12
- Dr. M. Ted Wong, DDS, MHA
Board-Certified Prosthodontist
Former Chief Dental Officer at UnitedHealthcare
Former Chief of the US Army Dental Corps
Bayer Paid Consultant
Dental professional organizations recommend
NSAIDs instead of opioids as first-line therapy for
acute pain management13-15
The American Dental Association recommends NSAIDs as
first-line therapy for acute pain management.13,14
The American Association of Oral and Maxillofacial Surgeons
recommends NSAIDs as first-line therapy for acute pain
management.15
The growing body of evidence offers a compelling argument
for first-line use of an NSAID like Aleve® for dental pain,
and the guidelines suggest ways of putting NSAIDs into
practice.1,5,6,13-15
When prescribing any product, HCPs should always consider
its efficacy and safety. Before any procedure requiring pain
management, dentists should talk with patients about the
benefits and risks of pain relief options.
" For dentists, this is an opportunity to play an active
role in alleviating the ongoing opioid crisis,10
and I
encourage all of my colleagues to consider using
effective non-opioid analgesics like Aleve® for
minor dental pain. " 1,2
- Dr. M. Ted Wong, DDS, MHA
Bayer Paid Consultant
References: 1. Cooper SA, Desjardins PJ, Bertoch T, et al. Analgesic effi cacy of naproxen
sodium versus hydrocodone/acetaminophen in acute postsurgical dental pain: a randomized,
double-blind, placebo-controlled trial. Postgrad Med. 2021. doi:10.1080/00325481.2021.
2008180 2. Aleve® Caplets. Drug facts. Bayer HealthCare; April 2018. 3. US Department of
Health and Human Services. Determination that a public health emergency exists. October 26,
2017. 4. Suda K, Zhou J, Rowan S, et al. Overprescribing of opioids to adults by dentists
in the U.S., 2011-2015. Am J Prev Med. 2020;58(4):473-486. doi:10.1016/j.amepre.2019.11.006
5. Data on fi le, Bayer Consumer Health. 6. Kiersch TA, Halladay SC, Hormel PC. A single-dose,
double-blind comparison of naproxen sodium, acetaminophen, and placebo in postoperative
dental pain. Clin Ther. 1994;16(3):394-404. 7. TYLENOL® with codeine Medication Guide.
Janssen Pharmaceuticals, Inc.; October 2019. 8. Manchikanti L, Singh A. Therapeutic opioids:
a ten-year perspective on the complexities and complications of the escalating use, abuse,
and nonmedical use of opioids. Pain Physician. 2008;11(2 Suppl):S63-S88. 9. Scholl L, Seth P,
Kariisa M, Wilson N, Baldwin G. Drug and opioid-involved overdose deaths-United States,
2013-2017. MMWR Morb Mortal Wkly Rep. 2019;67(51-52):1419-1427. 10. Denisco RC, Kenna
GA, O'Neil MG, et al. Prevention of prescription opioid abuse: the role of the dentist. J Am
Dent Assoc. 2011;142(7):800-810. doi:10.14219/jada.archive.2011.0268 11. Nalliah RP, Sloss KR,
Kenney BC, et al. Association of opioid use with pain and satisfaction after dental extraction.
JAMA Netw Open. 2020;3(3):e200901. doi:10.1001/jamanetworkopen.2020.0901 12. Katz J,
Smith S, Collins J, et al. Cost-eff ectiveness of nonsteroidal anti-infl ammatory drugs and
opioids in the treatment of knee osteoarthritis in older patients with multiple comorbidities.
Osteoarthritis Cartilage. 2016;24(3):409-418. doi:10.1016/j.joca.2015.10.006 13. American
Dental Association announces new policy to combat opioid epidemic. News release. American
Dental Association. March 26, 2018. Accessed July 28, 2021. https://www.prnewswire.com/
news-releases/american-dental-association-announces-new-policy-to-combat-opioidepidemic-300618928.html
14. American Dental Association. Statement on the use of opioids
in the treatment of dental pain. October 2016. Accessed October 14, 2021. https://www.ada.
org/en/advocacy/current-policies 15. American Association of Oral and Maxillofacial Surgeons.
Opioid prescribing: acute and postoperative pain management; 2020. White Paper. Accessed
July 28, 2021. https://www.aaoms.org/docs/govt_aff airs/advocacy_white_papers/opioid_
prescribing.pdf
Aleve, Bayer and the Bayer Cross are registered trademarks of Bayer.
All rights reserved. Unless otherwise indicated, all trademarks are owned by Bayer and its affi liates, or licensed for its use.
© 2021 Bayer December 2021 PP-AL-P-US-1603
FREE FACTS, circle 3 on card

https://www.prnewswire.com/ https://www.ada https://www.aaoms.org/docs/govt_aff

Dentaltown March 2022

Table of Contents for the Digital Edition of Dentaltown March 2022