Chester County Medicine Spring 2021 - 13

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Future Research and Important Remaining
Questions
As the SGLT2i is further explored and characterized, there a
few questions of immediate interest:
1. What important differences exist among the individual
SGLT2i derivatives?
Figure 17: SGLT2i treatments are recommended to patients to
prevent and treat heart failure

2. Will the benefits of the SGLT2i remain as a long-term
solution for patients?

Indications for SGLT2 inhibitors:

3. What other diabetic and cardiovascular medications can the
SGLT2i be combined with to offer beneficial outcomes?

·To reduce the risk of cardiovascular (CV) death and
hospitalization for heart failure in adults with heart failure
(NYHA class II-IV) with reduced ejection fraction
·To reduce the risk of hospitalization for heart failure in adults
with type 2 diabetes mellitus and established CV disease or
multiple CV risk factors
·As an adjunct to diet and exercise to improve glycemic control
in adults with type 2 diabetes mellitus

This article was written
in collaboration
between Mian A.
Jan, M.D., Chairman,
Department of Medicine
Penn Medicine Chester
County Hospital,
and Ankit Raina, an
intern at West Chester
Cardiology.

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Chester County Medicine Spring 2021

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