Central PA Medicine Summer 2021 - 20

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Features
Celebrating
By ADAM STURTS, DO
arly on October 31, 1920, the
Canadian orthopedic surgeon Sir
Frederick Banting, MD, awoke
suddenly with an idea that transformed
type 1 diabetes mellitus from a
certain death sentence to a treatable chronic
medical condition. He penned the idea in his
journal: " Diabetus. Ligate pancreatic ducts
of dog. Keep dogs alive till acini degenerate
leaving islets. Try to isolate the internal
secretion of these to relieve glycosurea. "
Thanks to the efforts of Banting and his
research team, John Macleod, Charles Best
and James Collip among others, insulin was
first isolated in 1921.
Prior to the discovery of insulin, there was
no effective treatment for type 1 diabetes.
Patients were prescribed starvation diets in a
futile attempt to prolong their short, agonizing
lives. Most died months after diagnosis.
Leonard Thompson, a 14-year-old type
20 Summer 2021 Central PA Medicine
100 Years of Insulin
E
1 diabetic, was the first to directly benefit
from the discovery of insulin. He was severely
malnourished, dehydrated and critically ill
with diabetic ketoacidosis when he presented
to Toronto General Hospital. After starting
insulin injections in 1922, his condition
improved and he lived for an additional 10
years. Dr. Banting and Macleod won the
Nobel Prize in Physiology of Medicine in 1923
for their discovery and this is still the fastest
time from discovery to Nobel Prize award.
Millions of diabetic lives have been saved
by insulin in the 100 years since discovery,
including my own.
My Experience with Insulin
I vividly remember the day I was diagnosed
with diabetes on August 5th, 1998, my 5th
birthday, and the first insulin injection that I
received. My initial insulin regimen included
pork insulin and NPH. The injections and
finger sticks for blood glucose monitoring
were painful, but I tolerated them because I
knew that without them I would be unwell.
My family supported me through these early
years. My friends affectionately nicknamed
me " Juice Box. " Support systems through
the Juvenile Diabetes Research Foundation
and Camp Nejeda, a camp for diabetic
children, were essential to my family's and
my own psychological wellbeing. Eventually,
I transitioned to insulin lispro and glargine
then insulin aspart and glargine.
In 2006, I got my first insulin pump, the
Medtronic MiniMed Paradigm 511. The
pump was truly a paradigm shift in the
management of my diabetes because it allowed
me to live more freely. I continued insulin
pump therapy throughout undergraduate
and physical therapy school and added a
Dexcom G4 Platinum CGM in medical
school with improvements in glycemic control
and glycemic understanding. Preparation for
medical residency not only included studying
medicine and clinical rotations but also
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Central PA Medicine Summer 2021

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