York County Medicine Summer 2019 - 12

YO R K C O M E D S O C . O R G

FEATURE:

UPMC PINNACLE STUDYING NEW
DEVICE FOR HEART FAILURE PATIENTS
First Hospital Worldwide to
Test Repair System in Clinical Trial
Harrisburg, Pa. (June 5, 2019) -- UPMC Pinnacle performed
the first procedure worldwide in a series of clinical trials testing an
investigational device aiming to manage heart failure symptoms by
repairing the left ventricle. UPMC Pinnacle is the first of up to 40
sites worldwide that will be enrolling patients in these trials.
An estimated 6.5 million U.S. adults live with heart failure and
suffer from debilitating symptoms including persistent exhaustion,
trouble breathing, confusion and loss of memory.1 Systolic heart
failure, which impacts up to 3.5 million patients2, is the result of the
left ventricle losing its ability to contract normally, thereby reducing
the ability of the heart to push enough blood to the rest of the body.
Called CorCinch-HFrEF, the U.S. clinical trial is an early
feasibility study of the AccuCinch® device, which is designed to
repair a weakening left ventricle which underlies the progression of
systolic heart failure.
"Patients with systolic heart failure have limited treatment
options available to them," said Hemal Gada, MD, MBA,
interventional cardiologist, medical director of the structural heart
program and principal investigator of the study at UPMC Pinnacle.
"This trial will be the first to test an alternative treatment approach
for patients with this debilitating and life-threatening condition."
During the AccuCinch procedure, a C-shaped device is placed
into the left ventricular wall, just below the mitral valve, using a
series of flexible catheters that are placed through a blood vessel in
the groin. Once properly positioned, the implant is then cinched
tight and secured in place. Once cinched, the AccuCinch implant
is intended to reduce the size of the left ventricle, as well as support
and strengthen the heart wall.
The CorCinch HFrEF and CorCinch EU clinical trials
are sponsored by Ancora Heart, Inc., which manufactures the
AccuCinch device. Up to 140 patients from the United States and
Europe will be enrolled in these trials.
In addition to the CorCinch trial, UPMC Pinnacle is enrolling
patients from the Harrisburg region in numerous additional
cardiovascular clinical trials. View a full list on the UPMC Pinnacle
website.
12

York County Medicine | SUMMER 2019

About UPMC
A $20 billion health care provider and insurer, Pittsburghbased UPMC is inventing new models of patient-centered, costeffective, accountable care. The largest nongovernmental employer
in Pennsylvania, UPMC integrates 87,000 employees, 40 hospitals,
700 doctors' offices and outpatient sites, and a 3.5 million-member
Insurance Services Division, the largest medical insurer in western
Pennsylvania. In the most recent fiscal year, UPMC contributed
$1.2 billion in benefits to its communities, including more care
to the region's most vulnerable citizens than any other health care
institution, and paid $587 million in federal, state and local taxes.
Working in close collaboration with the University of Pittsburgh
Schools of the Health Sciences, UPMC shares its clinical, managerial
and technological skills worldwide through its innovation and
commercialization arm, UPMC Enterprises, and through UPMC
International. U.S. News & World Report consistently ranks UPMC
Presbyterian Shadyside on its annual Honor Roll of America's Best
Hospitals. For more information, go to UPMC.com.
Benjamin E.J., Blaha M.J., Chiuve S.E., et al. Heart disease and stroke
statistics-2017 update: a report from the American Heart Association.
Circulation 2017; 135: pp. e146-e603

1

Yancy CW et al, JACC 2013

2


http://www.YORKCOMEDSOC.ORG http://www.UPMC.com

York County Medicine Summer 2019

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