NC Pork Report - Fall 2017 - 19

SPONSORED CONTENT

Efficacy Evaluation of guaifenesin solution in
drinking water of pigs exposed to H1N1 Swine
Influenza Virus and Pasteurella multocida
SUMMARY
The historical use of botanical expectorants was noted among tropical Americans using
Guaiac tree extracts in the 16th century. More recently gum of the Guaiacum spp., which
is approved in Europe and the U.S. as a food additive, was refined and eventually synthesized as guaifenesin. Seagrave et al. (2012) demonstrated some functions of guaifenesin
in vitro. When dosed on human respiratory cells, guaifenesin caused the cells' mucus to
become less viscous and less elastic. The resulting increase in fluidity was documented
by visually tracing the speed at which mucus transported contaminants across a field of
the mucosal cells. The data gave clear support for guaifenesin's mode of action in clearing mucus and trapped irritants more easily.
Extending the model to animals
More recently, Lechtenberg et al. (2016) have tested the technology in vivo in swine,
using their Swine Influenza Virus (SIV) challenge model to measure some guaifenesin
effects during a severe respiratory challenge. The work was carried out at Central States
Research Centre, Inc., Oakland, NE.

MATERIALS AND METHODS
Twenty-five healthy, 3- 4-week-old crossbred pigs of either sex were confirmed
SIV negative before arriving to the study
site. The pigs were without therapeutic
antimicrobial by any route 14 days prior
to challenge and had no history of SIV or
P. multocida vaccination. Pigs acclimated for 12 days before being challenged.
Study animals were randomized to placebo and treatment groups and housed in
one BSL-2 (5600 series) room. Pigs were
provided water ad libitum throughout the
study period, and were fed a grower ration
1

that did not contain therapeutic antimicrobials.
Twenty study pigs were challenged on day
0 intra-nasally with 4.0 mL containing
1x105.5TCID50/mL of H1N1 SIV. On day
3, study pigs were secondarily challenged
intra-nasally with 4.0 mL containing 1x108
CFU/mL of P. multocida.
The clinical signs of infection using this
model appear 1-3 days after SIV challenge. The treatment group received 7.4
mL of the guaifenesin-containing concentrate1 per gallon of drinking water begin-

MucuSolĀ®, provided by Animal Science Products, Inc., Nacogdoches, Texas.


http://asp-inc.com

Table of Contents for the Digital Edition of NC Pork Report - Fall 2017

Letter From the President
Industry News
Producer Profile
Legislative Update
Profile: Brandon Hartman
Sustained Excellence in Swine Production
Youth News
Pork Checkoff Announces
Advertiser Index
NC Pork Report - Fall 2017 - Intro
NC Pork Report - Fall 2017 - cover1
NC Pork Report - Fall 2017 - cover2
NC Pork Report - Fall 2017 - 3
NC Pork Report - Fall 2017 - 4
NC Pork Report - Fall 2017 - 5
NC Pork Report - Fall 2017 - Letter From the President
NC Pork Report - Fall 2017 - 7
NC Pork Report - Fall 2017 - Industry News
NC Pork Report - Fall 2017 - 9
NC Pork Report - Fall 2017 - 10
NC Pork Report - Fall 2017 - 11
NC Pork Report - Fall 2017 - 12
NC Pork Report - Fall 2017 - 13
NC Pork Report - Fall 2017 - 14
NC Pork Report - Fall 2017 - Producer Profile
NC Pork Report - Fall 2017 - 16
NC Pork Report - Fall 2017 - 17
NC Pork Report - Fall 2017 - 18
NC Pork Report - Fall 2017 - 19
NC Pork Report - Fall 2017 - 20
NC Pork Report - Fall 2017 - 21
NC Pork Report - Fall 2017 - 22
NC Pork Report - Fall 2017 - 23
NC Pork Report - Fall 2017 - Legislative Update
NC Pork Report - Fall 2017 - 25
NC Pork Report - Fall 2017 - Profile: Brandon Hartman
NC Pork Report - Fall 2017 - 27
NC Pork Report - Fall 2017 - Sustained Excellence in Swine Production
NC Pork Report - Fall 2017 - 29
NC Pork Report - Fall 2017 - 30
NC Pork Report - Fall 2017 - 31
NC Pork Report - Fall 2017 - Youth News
NC Pork Report - Fall 2017 - 33
NC Pork Report - Fall 2017 - Pork Checkoff Announces
NC Pork Report - Fall 2017 - 35
NC Pork Report - Fall 2017 - 36
NC Pork Report - Fall 2017 - 37
NC Pork Report - Fall 2017 - Advertiser Index
NC Pork Report - Fall 2017 - cover3
NC Pork Report - Fall 2017 - cover4
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