The Column - May 2007 - (Page 28)

Q&A The Column www.thecolumn.eu.com May 2007 Highly Sensitive The ActiPix D100 detector won the Editors’ Silver Award for best new product at Pittcon 2007. The Column spoke to Professor David Goodall, chief scientific officer at Paraytec, about the development of this exciting new product and the benefits it offers separation scientists. independent of any light fluctuations, resulting in a very stable absorbance signal output. The area imager is an active pixel sensor, similar to those used in mobile phones and digital cameras. The readout of signals on the sensor and absorbance calculations are performed at megahertz (MHz) rates, with all the processing done in hardware on custom electronic assemblies. As an analyte travels through the capillary, hundreds of snapshots can be taken in the time taken to move across the array. These What is innovative about this unique signal-processing algorithms product? recognize that the analyte travels at Paraytec’s patents show that the capillary constant velocity and use the appropriate acts as a sample vessel and a cylindrical time displacement to add together and lens, which in conjunction with an area average the snapshots. array detector provides a unique selfThe analyte signals are correlated referencing system for absorbance whereas the noise is uncorrelated, so the detection. net result is a gain in signal-to-noise (S/N) This is innovative because we use an ratio proportional to the square root of the area imaging array instead of the more number of snapshots. Processed data is commonly used linear photodiode array. outputted in real-time to a computer using Looking across the capillary, the lensing Professor David Goodall, chief an industry-standard high-speed serial effect separates rays of light travelling scientific officer at Paraytec. data link. through the sample from those passing Another innovation is multiplexed detection. This means that through the walls or the outside of the capillary. This allows up to eight capillaries can be imaged in parallel using the area light passing through the sample in the capillary to be readily sensor, allowing high throughput and increased productivity in referenced against light from the same source. The major a miniature format. benefit of using this self-referencing process is that it is The ActiPix D100 is the world’s first capillary ultraviolet (UV) area imaging detector. It was designed for use with separation methods such as nanobore liquid chromatography (nanoLC) and capillary electrophoresis (CE), which require single wavelength UV absorbance measurements on picolitre to nanolitre volumes with high sensitivity without sacrificing spatial resolution. Author: David Goodall E-mail: david.goodall@paraytec.com What is the ActiPix D100 detector? 28 http://www.thecolumn.eu.com

Table of Contents for the Digital Edition of The Column - May 2007

Contents
News
Using LC–MS to Extend the Time Window for Detecting Drugs
Zosimus
Market Trends and Analysis
Etched Chemically Modified Capillaries: Novel Separation Medium for Electrophoretic Analyses
Q&A
Shaping the Future
Special Section: Shidadzu - LC World Talk

The Column - May 2007

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