The Column - May 2009 - (Page 6)

Welch The Column www.thecolumn.eu.com May 2009 Lorcan/Getty Images Is Green the New Black? “Green” separation techniques have been going in and out of fashion since the early 1980s. Is the renewed interest in green chromatography marketing hype or is the chromatography community beginning to treat this topic seriously? Alasdair Matheson spoke to Chris Welch from Merck’s Separation & Purification Centre of Excellence in Rahway, New Jersey, USA to find out more. Does separation science need to undergo a green revolution? The short answer is yes, but with varying levels of urgency that depend upon the area of separation science. Clearly, the most urgent need for greener separation processes lies where current approaches are generating very large amounts of waste, typically in areas like mining, refining and industrial-scale manufacturing. But, with waste reduction, every little bit helps, so modest savings in techniques that are broadly used, for example, laboratory-scale separations, can also have a substantial cumulative effect. It’s almost an axiom with separation science that in order to make one thing clean, we end up making lots of something else dirty. The challenge for greening separation science is to find ways to bring about the required purification or separation with a net reduction in the amount of waste generated, hopefully using a technology that is also comparable in cost. Often, the green alternative ends up being more economical when costs relating to waste disposal are taken into consideration. At Merck, we are committed to the development of lean and efficient, environmentally benign methods. Our scientists have been working for a number of years on greening chemistry and engineering, particularly as it relates to the commercial manufacturing of drugs. Key drivers for this focus have been a mixture of good Contact author: E-mail: Chris Welch christopher_welch@merck.com environmental stewardship, regulatory compliance and pure economics, driven largely by the increasing cost of waste disposal. Separation science is an important part of the green chemistry and engineering effort because extractions, washes and various purification processes account for a significant fraction of the waste that is generated in the production of a typical pharmaceutical. LC•GC readers will be most interested in the role that chromatography and adsorption play in this story. Preparative chromatography is increasingly being used in pharmaceutical manufacturing, and green preparative chromatography technologies are essential for commercial feasibility. Preparative chromatography can use hundreds of litres of solvent for every kilogramme of product that is purified. Not surprisingly, solvent recycle and recovery have long been an important focus in this field, and many technological improvements are currently being introduced to further reduce solvent consumption. In the past, waste generated in drug discovery and development was simply chalked up as an unavoidable cost of doing business, but waste reduction in this area has become increasingly important with the recent aggressive focus on productivity in all activities in drug discovery and development. Companies are beginning to realize that even in areas such as analytical chromatography, small amounts of waste, multiplied by the hundreds or thousands of workers in a typical pharma company can be substantial. 6 http://www.thecolumn.eu.com

Table of Contents for the Digital Edition of The Column - May 2009

The Column - May 2009
Contents
Q&A: Is Green the New Black?
News
Incognito
Market Trends and Analysis
Quantification of Pharmaceuticals from Diminishing Small Volumes of Blood Using the UHC Small Molecule Chip Coupled to Triple Quadrupole MS
An Investigation of the Impact of Common Experimental Parameters on Signal Intensity in SFC–ESI-MS
Multicolumn Preparative SFC: An Advanced Solution to Scale-up Difficulties
Introduction to HPLC 2009
HPLC 2009 Guide

The Column - May 2009

http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn030713_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn030713
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn030713_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn021813_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn021813
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn021813_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn020413_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn020413_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn020413
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn011513_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn011513_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn011513
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn120312_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn120312_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn120312
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn112112_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn112112
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn112112_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn110712_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn110712
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn110712_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn102412_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn102412_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn102412
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn100412_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn100412_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn100412
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn092012_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn092012_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn092012
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn090612_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn090612_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn090612
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn082212_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn082212_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn082212
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn080212_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn080212_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn080212
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn071812_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn071812_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn071812
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn070412_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn070412_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn070412
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn062212
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn062212_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn062212_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn060812_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn060812_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn060812
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn051712_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn051712
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn051712_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn050212_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn050212_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn050212
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn041912_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn041912_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn041912
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn040212mkt
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn040212_v3
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn040212_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn040212
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn032112
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn032112_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn030712_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn030712
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn022212_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn022212
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn020112_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn020112
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn011612
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn011612_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn120611
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn120611_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn111611
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn111611_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn110711_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn110711
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn101711
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn101711_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn100711
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn100711_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn092111_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn092111
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn090611_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn090611
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn082211_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn082211
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn080511_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn080511
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn071511_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn071511
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn070111_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn070111
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn061711_hplc
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn061711_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn061711
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn060611_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn060611
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn051811
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn051811_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn050911_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn050911
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn041811_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn041811
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn040111_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn040111
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn031811_v2_test
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn031811_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn031811
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn03042011_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn03042011
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn022111_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn022111
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn020411
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn020411_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn012411_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn012411
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn012711_pittcon
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn120710_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn120710
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn111910
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn111910_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn110510_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn110510
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn102210_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn102210
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn100810_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn100810
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn092410_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn092410
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn090710
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn090710_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn082010v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn082010
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn080610_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn080610
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn072310
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn072310_v2
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn070210
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn062110
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn060710
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn052410
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn051010
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn042310
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn040610
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn031910
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn030510
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn022210
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn020510
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn012210
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn121709
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn120709
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn111909
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn110509
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn102209
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn100809
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn092409
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn090409
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn082009
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn0809
http://digital.findanalytichem.com/nxtbooks/advanstaruk/thecolumn0709_v2
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0709
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0609
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0509
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0409
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0309
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0209
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0109
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1208
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1108
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1008
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0908
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0808
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0708
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0608
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0508
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0408
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0308
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0208
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0108
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1107f8
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1207
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1107
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1007
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0907
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0807
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0707
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0607
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0507v2
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0507
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0407-insert
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn-shimadzu0407
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0407
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0307
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0207
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0107
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1206
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1106
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1006
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0906
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0806
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0706
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0606
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0506
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0306
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0206
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn0106
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1105s
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1205
https://www.nxtbook.com/nxtbooks/advanstaruk/thecolumn1105
https://www.nxtbookmedia.com