APMA News - July/August 2019 - 19

Orthofix Bone Healing Solutions
Dynamic I Differentiated I Restorative

Orthofix PhysioStim™ devices create a pulsed electromagnetic field
(PEMF) that stimulates fracture repair.1
PEMF impacts bone healing at a:
* Molecular Level: Within 10 minutes of PEMF exposure, signaling
pathways are activated2
* Cellular Level: PEMF stimulates bone cells to proliferate,
differentiate and mineralize3,4
* Tissue Level: PEMF has been shown to improve quality of bone
tissue and enhance bone preservation5-7

Trinity ELITE ™ allograft offers an enhanced handling experience, while
providing the three essential physiologic components for new bone
formation:
* Verified osteoinductive potential
* Osteoconductive scaffold
* Viable osteogenic cells retained within the cancellous matrix
Exclusively processed by MTF Biologics.

Visit booth #1001 at the APMA Annual Meeting
to see our product portfolio
1. PMA P850007. February 1986. 2. Schnoke M, Midura RJ. Pulsed electromagnetic fields rapidly modulate intracellular signaling events in osteoblastic cells: comparison to parathyroid hormone and insulin. J Orthop Res. 2007;25(7):93340. 3. Selvamurugan N, Kwok S, Vasilov A, Jefcoat SC, Partridge NC. Effects of BMP-2 and pulsed electromagnetic field (PEMF) on rat primary osteoblastic cell proliferation and gene expression. J Orthop Res. 2007;25(9):1213-20. 4.
Selvamurugan N, He Z, Rifkin D, Dabovic B, Partridge NC. Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation. Stem
cells international. 2017 Apr 23;2017. doi.org/10.1155/2017/2450327. 5. Ibiwoye MO, Powell KA, Grabiner MD. Bone mass is preserved in a critical-sized osteotomy by low energy pulsed electromagnetic fields as quantitated by in
vivo micro-computed tomography. J Orthop Res. 2004;22(5):1086-93. 6. Midura RJ, Ibiwoye MO, Powell, KA, et al. Pulsed electromagnetic field treatments enhance the healing of fibular osteotomies. J Orthop Res. 2005;23:1035-46. 7.
Androjna C, Fort B, Zborowski M, Midura R. Pulsed electromagnetic field treatment enhances healing callus biomechanical properties in an animal model of osteoporotic fracture. Bioelectromagnetics. 2014; 35(6): 396-405.

Brief Prescribing Information:
The PhysioStimª device is indicated for the treatment of an established nonunion acquired secondary to trauma, excluding vertebrae and all flat bones, where the width of the nonunion defect is less than one-half the width
of the bone to be treated. A nonunion is considered to be established when the fracture site shows no visibly progressive signs of healing. Use of this device is contraindicated where the individual has synovial pseudarthrosis.
Demand type pacemaker operation may be adversely affected by exposure to pulsed electromagnetic fields. The safety and effectiveness of this device has not been established for individuals lacking skeletal maturity or
individuals with a nonunion secondary to, or in connection with, a pathological condition. The safety of this device for use on patients who are pregnant or nursing has not been established.
Rare instances of reversible minor discomfort have been reported. Full prescribing information can be found in product labeling on our patient education website
www.BoneGrowthTherapy.com or by calling Patient Care at 1-800-535-4492.
Caution: Federal law (USA) restricts this device to sale by or on the order of a physician.
Orthofix products or services referenced herein are trademarks or registered trademarks of Orthofix
Medical Inc. and its group of companies. Any rights not expressly granted herein are reserved.

Orthofix.com
BoneGrowthTherapy.com
OFS-AD-1935.2 © Orthofix Holdings, Inc. 6/2019

http://www.doi.org/10.1155/2017/2450327 http://www.BoneGrowthTherapy.com http://www.Orthofix.com http://www.BoneGrowthTherapy.com

APMA News - July/August 2019

Table of Contents for the Digital Edition of APMA News - July/August 2019