introduction Cleaning validation programs are essential to cGMP manufacturing to ensure product quality and patient safety. Total organic carbon (TOC) testing is a compliant method to demonstrate cleanliness of equipment. Unlike specific methods, TOC gives a comprehensive understanding of cleanliness while gaining process efficiencies. Whether you are new to cleaning validation or a seasoned TOC user, this e-book will provide all levels a wide-ranging understanding of the what, how, and why of TOC for cleaning validation. 3