Children's Hospitals Today - Spring 2017 - 10

ROUNDS / RESEARCH

Secondhand stress

IN BRIEF

A mom's stress during pregnancy could have
a long-term effect on baby's health.

S

tress, which can cause depression and
anxiety, is best avoided-especially if
a woman is pregnant, according to a new
study presented at the annual meeting of
the Society for Neuroscience.
The research showed that anxiety and
cognitive problems in adulthood can be
traced back to a mother's stress levels
during pregnancy. That stress, which
could alter the makeup of bacteria in
a pregnant mother's intestine and placenta, could also be responsible for longterm alterations of her female offspring's
intestinal tracts.
When pregnant mice were exposed to
stress in the study, they were anxious,
spent more time in dark, closed spaces,
and they had a harder time learning cognitive tasks. The female offspring of the

Share your hospital's latest
research. Email magazine@
childrenshospitals.org.

10

CHILDREN'S HOSPITAL S TODAY Spring 2017

CROHN'S PATIENTS
REACH REMISSION
WITH DIET THERAPY
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stressed mothers also performed worse
on anxiety and cognitive tests even
though they didn't encounter any stress
after birth. Researchers say the female
offspring also displayed greater anxietylike behavior and had a decreased ability to learn when compared with female
mice from a non-stressed mother. The
team found changes in the male offspring, but the details of that part of the
study are still in the works.
Researchers say this study, along with
others previously conducted on humans,
suggest mental health issues faced by
people later in life could be a result of
the microbial changes that take place in
the placenta when the mother is stressed
during pregnancy.

Standard treatment for conditions like Crohn's disease
can leave patients vulnerable to infections, increase
the risk of diabetes, sap energy, halt growth and spark
incessant diarrhea. Seattle
Children's Hospital is leading
research on the specific carbohydrate diet (SCD), which
has helped some patients
achieve remission without
medication. SCD eliminates
most grains and sugars, but
no one fully understands
why it works. The hospital
is conducting a study that
genetically sequences participants' gut bacteria before
and after the diet.

ANTIBIOTIC-RESISTANT
INFECTIONS ON THE RISE
Rising infection rates caused
by Enterobacteriaceae, a
bacteria resistant to multiple
antibiotics, are leading to
longer hospitalizations and
may mean a higher risk of
death for children, according
to a study published in
February in the Journal of the
Pediatric Infectious Diseases
Society. Researchers found
three out of five children
admitted to hospitals already
had an antibiotic-resistant
infection, suggesting the
infections are spreading in
the community. According
to the study, the proportion
of those infections rose
almost 700 percent, from
0.2 percent to 1.5 percent in
about eight years.



Table of Contents for the Digital Edition of Children's Hospitals Today - Spring 2017

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Children's Hospitals Today - Spring 2017 - Contents
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