Immunotherapy and Cancer: Harnessing the Power of Diagnostic Assays - 11

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Receptor-Specific Cells

PAST

Tumor-Specific Immune Cells

PRESENT

Empirically
Prescribed Therapies

FUTURE

Precision and Personalized Therapies
Targeted Therapy

Immunotherapies

Dx Testing Today for
Targeted Therapies

The Dx Testing Future
for Immunotherapies

The

TIS

PCR

Targeted Drugs:
Usually One Drug, One Dx

E
R
A
P
Y

I-O Drugs are likely to be administered
in combination with a Targeted
Therapy or other I-O Drugs

FROM

TO

Tissue Specific Targeted Therapies

Tumor Agnostic Therapy
ND
GA N
IM IN T IO
P R T IVA
AC

ROS1
LUNG
CANCER

ALK

MELANOMA

KRAS

EGFR

CA N CE
R AN
TI
PR ES
EN TA G EN
TI O N

C
H
E
M
O
T
H

BRAF

COLORECTAL
CANCER
PIK3CA

Download
PDF

HOT TUMOR
11

A Clinical OMICs eBook	

ERBB2

KRAS

The

EVOLUTION
of
CANCER
THERAPIES
and
BIOMARKERS

A Smart Bomb

TUMOR
CELL

A biomarker identifies a
tumor's vulnerability
and the right drug
is prescribed to
exploit its weakness.

Immunomodulators

COLD TUMOR

Invisible to the
immune system with few to
no tumor antigens or T-Cells.

turn cold tumors to hot:
Cancer Vaccines
Oncolytic Viruses
T-Cell Engagers
Innate ImmuneActivators
Myeloid Cell Immune
Modulators

MELANOMA

BREAST
CANCER

COLORECTAL
CANCER

OTHER
CANCERS

KILLING OF
CANCER CELLS

BRAF

Targeted Therapy

T
T-C RAFF
ELL ICK
S T ING
OT
O
UM F
OR
S

LUNG
CANCER

ER
NC
CA NS
OF GE
E TI
AS AN
LE LL
RE CE

BREAST
CANCER

COLD TUMOR

100% of
Patients

MSI
IHC

R A D I AT I O N

View Full
Screen

TMB

Complex

Simple

100% of
Patients

&/or

OF
RATION
S
INFILT TO TUMOR
S IN
T-CELL

EVOLUTION OF
CANCER THERAPIES
AND BIOMARKERS

IHC

R
CA EC
NC OG
ER NI
BY T I O
T- N O
CE F
LL
S

View Full Screen

All Cells

Immunotherapies

Redirecting the Host Immune System
Relies on dynamic interactions between
tumors and immunomodulators in the
tumor microenvironment.

Killer T-cells destroy infected
cells. To distinguish between
healthy and infected
cells they identify
antigens.
T-CELL

TUMOR
CELL

APCs
HOT TUMOR

Highly visible to the
immune system with high
numbers of antigens and T-Cells.

APCs
(antigen-presenting cells)
fight tumors via stimulation of B and
cytotoxic T-cells that produce antibodies
against tumor-related antigens.

https://nxt-staging-books.s3.amazonaws.com/nxtbooks/clinicalomics/mmd_201806/src/docs/MMD_IG2_final.pdf https://nxt-staging-books.s3.amazonaws.com/nxtbooks/clinicalomics/mmd_201806/src/docs/MMD_IG2_final.pdf https://nxt-staging-books.s3.amazonaws.com/nxtbooks/clinicalomics/mmd_201806/src/docs/MMD_IG2_final.pdf https://nxt-staging-books.s3.amazonaws.com/nxtbooks/clinicalomics/mmd_201806/src/docs/MMD_IG2_final.pdf

Table of Contents for the Digital Edition of Immunotherapy and Cancer: Harnessing the Power of Diagnostic Assays