ASH News Daily 2014 - Day 1 - (Page A-1)

Read this issue online at Follow us on Twitter using #ASH14 Schedule 11:15 a.m. - 12:15 p.m. Grassroots Network Lunch InterContinental San Francisco (Grand Ballroom A-B) 11:15 a.m. - 12:15 p.m. Continuing Conversations with the Speakers Moscone Center (South Building, Esplanade 302) 12:30 - 1:30 p.m. Ham-Wasserman Lecture Moscone Center (North Building, Hall D) 2:00 - 3:30 p.m. Special Symposium on Quality Moscone Center (West Building, 3002-3004-3006-3008) 4:00 - 5:30 p.m. Special Scientific Symposium on RNA Therapeutics in Hematology Moscone Center (West Building, 3007-30093011-3020-3022-3024) 6:30 - 9:00 p.m. Promoting Minorities in Hematology Presentations and Reception InterContinental San Francisco (Grand Ballroom A-C) Today at 3:30 - Editors at the ASH Booth! Meet the Editors-in-Chief of The Hematologist (Dr. Jason Gotlib) and ASH Clinical News (Dr. Mikkael Sekeres) today, from 3:30 to 4:00 p.m. at the ASH Booth (#1305). WiFi Networks There are two WiFi networks at the Moscone Center: The "ASH Plenary" network is exclusively for Sunday's Plenary Scientific Session in Hall D. The "ASH14" network is for all other areas of the convention center. You will only have to log on to each WiFi network once. IN THIS SECTION Trainee Day A-6 Stem Cells A-18 Iron Overload A-19 Do These Genes Make My Cancer Look Bad? By Benjamin Watkins, MD, and Robert Sheppard Nickel, MD O ne of the greatest medical triumphs during the past half-century has been the treatment of pediatric acute lymphocytic leukemia (ALL) with event-free survival approaching 90 percent. Despite this success, ALL remains the leading cause of cancer-related death in children. The advancing field of cancer genomics offers great potential as we strive to further improve our battle against ALL and other cancers. The education program session "Insights from Pediatric Hematologic Malignancies: Focus on Acute Lymphocytic Leukemia" will provide an update on pediatric ALL, addressing this evolving topic. The session will be offered twice today, from 7:30 to 9:00 a.m. (North Building, Rooms 120-125) and from 4:00 to 5:30 p.m. (Marriott Marquis, Yerba Buena Ballroom Salon 9). In part one of the session, Dr. Charles Mullighan of St. Jude Children's Research Hospital will present recent breakthroughs in genome-wide profiling of ALL that has identified new subtypes of ALL, including early T-cell precursor ALL, Ph-like ALL, and ALL with intra- chromosomal amplification of chromosome 21. He will explain how genomics has led to changes in risk stratification and the identification of potential new therapeutic targets. »» GENETIC Page A-14 Dr. Radovan Vrhoval, Croatia, snaps a photo of the #ASH14 I Love Hematology display in the lobby of the Moscone West building. Who's Counting? Scientists Tackle the Complexity of Age and Blood Disease By Laura Michaelis, MD A ge matters. This is no surprise to clinicians, scientists, or to most of our older patients. While predicting the likely toxicities of therapy for individual patients has long been considered part of the "art" of our profession, there is rapidly accumulating basic and translational research on how age and comorbidities both help predict treatment tolerance and intersect with disease pathogenesis and therapeutic efficacy. A dynamic scientific workshop on Friday titled "Hematology and Aging: Highlighting Novel Science and Developing a Research Agenda," gave attendees a chance to hear from more than a dozen researchers on topics from the impact of aging on stem cell mutation frequency, to new data on how comorbidities in the older patient modify the risk for developing graftversus-host disease (GVHD).The interactive forum was spearheaded by Dr. Heidi Klepin, who has published innovative research on the assessment of older patients with leukemia. Dr. Klepin and others first envisioned the symposium at an ad-hoc get-together during the 2013 ASH Annual Meeting. "The idea for the workshop grew out of the grassroots efforts of clinical and basic science researchers who were interested in promoting and »» AGING Page A-14

Table of Contents for the Digital Edition of ASH News Daily 2014 - Day 1

Table of Contents

ASH News Daily 2014 - Day 1