ASH News Daily 2015 - Day 1 - (Page A-1)

ASH NewS DAily ® 57th Annual Meeting of the American Society of Hematology Issue 1, Section A Saturday, December 5, 2015 Orlando, FL Read this issue online at Follow us on Twitter using #ASH15 SchedUle 7:30 - 9:00 a.m. Special Scientific Symposium on Targeting the Epigenome Orange County Convention Center (Hall E1) 11:15 a.m. - 12:15 p.m. Grassroots Network Lunch Hyatt Regency Orlando (Orlando Ballroom N) 11:15 a.m. - 12:15 p.m. How to Get Published in a Peer-Reviewed Journal Orange County Convention Center (Tangerine 1 - WF1) 12:30 - 1:30 p.m. Ham-Wasserman Lecture Orange County Convention Center (Hall D) 2:00 - 3:30 p.m. Special Symposium on Quality Orange County Convention Center (W304) 2:00 - 3:30 p.m. Special Scientific Symposium on Precision Medicine in Cancer Therapy: N-of-1 Orange County Convention Center (Hall E1) 4:00 - 5:30 p.m. Special Scientific Symposium on Genomically Engineered Stem Cells: A Brave New World for Therapeutics Orange County Convention Center (Hall E1) 6:30 - 9:00 p.m. Promoting Minorities in Hematology Presentations and Reception Hyatt Regency Orlando (Regency Ballroom O-P, Ballroom Q) IN THIS SECTION Trainee Day A-6 No Match? A-10 Quality A-16 Where Have All the Neutrophils Gone? By Saad USmani, md N eutrophils are the foot soldiers of the innate immune system "army" - first responders to a site of infection, laboring to keep the microbial "enemy" in check until the adaptive immune system kicks in. Benign variations in neutrophil quantity are well recognized in certain populations and are of little clinical consequence. For example, individuals of African or Middle Eastern descent have low neutrophil counts (neutropenia) due to polymorphisms in the Duffy-Antigen receptor of chemokines (DARC) gene, which is associated with protection against malaria. However, the congenital forms of neutropenia (termed "severe congenital neutropenia" [SCN]) are clinically significant. First described by Dr. Rolf Kostmann in 1956, SCN not only makes individuals prone to life-threatening infection, it may also evolve into myelodysplastic syndrome and acute leukemia. SCN is a heterogeneous group of disorders characterized by the presence of several distinct gene mutations, the most common of which are the autosomal-dominant HAX1 and ELANE gene mutations. This year's Ham-Wasserman lecture has been awarded to Dr. Ivo Touw, and this afternoon he will provide an overview of the progress made in understanding SCN in a talk titled "Game of Clones: Genomic Evolution of Severe Congenital Neutropenia," taking place from 12:30 p.m. to 1:30 p.m. in Hall D, Level 2 (Orange County Convention Center). The Ham-Wasserman lectureship is named after Dr. Thomas H. Ham »» HAM-WASSERMAN Page A-21 Dr. Marieke Essers gives her presentation in the Friday Scientific Workshop on Myeloid Development. Appetite for Invention: Why the Workshop on Myeloid Development Is a Tasting Menu of Discovery By aaron GerdS, md I n 1953, Winston Churchill intoned that "Without tradition, art is a flock of sheep without a shepherd. Without innovation, it is a corpse." For more than two decades, the Workshop on Myeloid Development has shepherded the art of hematology research, fuel- ing innovation with stimulating discussions and building a yearly tradition of collaboration and scientific discovery. "The workshop was started by a small group of friends who wanted to talk about myeloid biology," co-chair Dr. Leonard Zon recalls of the workshop's origins. With continued growth over time, he said, "ASH became involved and really helped maintain it." This year's session, held on Friday afternoon, was broken down into several sessions by topic: stem cells, signaling, myeloid malignancies, transcription factors, and animal models. Co-chair Dr. Alan Rosmarin stressed that the rules of engagement - limiting lecturing and fostering conversation - have proven over the years to »» MYELOID Page A-22

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ASH News Daily 2015 - Day 1