ASH News Daily 2015 - Day 4 - (Page A-1)

ASH NEWS DAILY ® 57th Annual Meeting of the American Society of Hematology Issue 4, Section A Tuesday, December 8, 2015 Orlando, FL Read this issue online at Follow us on Twitter using #ASH15 SCHEDULE Clot Prevention by Apples and Onions? The PDI Story in Full Color BY JEANNE PALMER, MD 7:00 a.m. - 1:30 p.m. Registration Orange County Convention Center West Building, Level 1 Concourse 7:30 - 9:30 a.m. Late-Breaking Abstracts Session Orange County Convention Center (Hall D) 9:30 - 9:45 a.m. Announcement of Awards: William Dameshek Prize, Henry M. Stratton Medal Orange County Convention Center (Hall D) 9:45 - 11:15 a.m. Presidential Symposium Orange County Convention Center (Hall D) 11:15 - 11:30 a.m. Business Meeting Orange County Convention Center (Hall D) 11:30 a.m. - 1:00 p.m. Best of ASH Orange County Convention Center (Hall D) O n Monday, ASH honored Barbara Furie, PhD, and Bruce Furie, MD, with the E. Donnall Thomas Lecture and Prize for their groundbreaking research in hemostasis and thrombosis. They presented their lecture, titled "Thiol Isomerases as Potential Regulators Controlling the Initiation of Thrombus Formation," in a morning general session. Dr. Bruce Furie is the chief of hemostasis-thrombosis at Beth Israel Deaconess Medical Center, the director of the Blood Coagulation and Vascular Biology Training Program, and professor of medicine at Harvard Medical School. Dr. Barbara Furie is professor emeritus at Harvard Medical School. They have been involved in hemostasis and thrombosis research since the 1970s and have achieved a number of impressive accomplishments, including the role of thiol isomerases in thrombus formation, which was discussed today. Drs. Barbara and Bruce Furie did not anticipate developing a career in hematology. At 16 years of age, Dr. Bruce Furie founded a summer sailing school and a sail- boat rental agency, Furie Sailing, on Long Beach Island in New Jersey. He had more than 40 rental boats and taught thousands how to sail. »» FURIES Page A-5 Keep Calm, It's Just the Proteasome BY SAAD USMANI, MD T IN THIS SECTION Late-Breaking A-2 Childhood ALL A-3 Immunotherapy A-4 Health-care Costs A-7 Dr. Alfred Goldberg he proteasome has been likened to the garbage disposal unit of the cell. It "grinds" down ubiquinated protein that is no longer needed by the cell into tiny bits, readying them for elimination. There are many moving parts to the proteasome machinery, and they all work together to maintain protein homeostasis. Since its discovery in the 1980s, the proteasome has emerged as an attractive targeted therapy in cancer in general and multiple myeloma specifically. This year's Ernest Beutler Lecture and Prize was awarded to Dr. Paul Richardson of Dana-Farber Cancer Institute and Dr. Alfred Goldberg of Harvard Medical School. On Monday, they presented their lecture, "Understanding the Proteasome: From Protein Degradation to Disease Therapy." They are being recognized for their noteworthy research discoveries in the area of proteasome inhibitors and their development as novel therapies for multiple myeloma. Dr. Goldberg is professor of cell biology at Harvard Medical School. He is an elected member of the National Academy of Sciences and the American Academy of Arts and Sciences, as well as a fellow of the American Association for the Advancement of Science. His efforts have spanned more than three decades and have been pivotal in understanding normal plasma cell biology and the role of the proteasome/ubiquitination pathway. During the lecture, he shared his own narrative - a scientific and professional journey that epitomizes bench-to-bedside research. He discussed the rationale for developing proteasome inhibition as »» BEUTLER Page A-4

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ASH News Daily 2015 - Day 4