ASH News Daily 2016 - Issue 3 - A-19
10"
Visit us at booth 2141
NOW RECRUITING
Newly Diagnosed FLT3-ITD (+) AML
in Patients aged 18 - 75
Quizartinib Advancement into the Next Generation of Trials for Unmet Needs in AML
A Phase 3, Randomized, Double-Blind, Placebo-controlled Study of Quizartinib (AC220) Administered in
Combination With Induction and Consolidation Chemotherapy, and Administered as Maintenance Therapy
in Subjects 18 to 75 Years Old With Newly Diagnosed FLT3-ITD (+) Acute Myeloid Leukemia
Cytarabine*
+
Anthracycline**
+
Quizartinib
NEWLY
DIAGNOSED
FLT3-ITD (+)
AML
Induction*
14"
18-75 years of age
ECOG 0-2
N≈536
AML=acute myeloid leukemia; FLT-3=FMS-like
tyrosine kinase 3; HSCT=hematopoietic stem cell
transplant; ITD=internal tandem duplication;
* Cycle 1 consists of 7+3 regimen. Alternate dosing
option for Cycle 2 can include a 5 + 2 regimen.
High-Dose
Cytarabine
+
Quizartinib
Quizartinib
(1-2 cycles)
(up to 4 cycles) and/or HSCT
Consolidation
Maintenance
Cytarabine*
+
Anthracycline**
+
Placebo
High-Dose
Cytarabine
+
Placebo
Placebo
(up to 12 cycles)
** Daunorubicin / Idarubicin
Scan here &
Primary Endpoint: Event-free Survival (EFS)
Secondary Endpoints:
* Overall Survival (OS)
* Complete Remission (CR)
* Composite Complete Remission (CRc)
* CR with no evidence of minimal residual disease (MRD)
Learn more
Location: North America, Europe, Asia/Other Regions | ClinicalTrials.gov Identifier: NCT02668653
Quizartinib is an investigational agent and is not approved by the FDA or other regulatory agencies
worldwide as a treatment for any indication. Efficacy and safety have not been established. There is
no guarantee that quizartinib will become commercially available.
For more information about this clinical trial, please visit
www.clinicaltrials.gov/ct2/show/NCT02668653 or
www.QuantumFirstStudy.com
Daiichi Sankyo, Inc · Two Hilton Court · Parsippany, NJ 07054
© 2016 Daiichi Sankyo, Inc.
All rights reserved.
Printed in US 2016
DSON16100267
09/16
www.dsi.com
Name: DSON16100267_Q_First_Trial_Card_Ad_Magazine_10X14.indd (Trial Ad). King page Ad. Advertiser: Daiichi Sankyo, Inc.; INK: 4 color process, with bleed. Size: 10 9/7/2016
x 14.
Previous Job: DSON16100244_Q_First_Trial_Card_Ad_Magazine_10X14.indd DSON16100209_Q_First_Trial_Card_Ad_Magazine_10.25X14 AND DSON16100190_Q_First_Tri-
DSON16100267_Q-First_Trial_Ad_Visit-Booth_10X14.indd 1
10:53:39 AM
Table of Contents for the Digital Edition of ASH News Daily 2016 - Issue 3
ASH News Daily 2016 - Issue 3 - A-1
ASH News Daily 2016 - Issue 3 - A-2
ASH News Daily 2016 - Issue 3 - A-3
ASH News Daily 2016 - Issue 3 - A-4
ASH News Daily 2016 - Issue 3 - A-5
ASH News Daily 2016 - Issue 3 - A-6
ASH News Daily 2016 - Issue 3 - A-7
ASH News Daily 2016 - Issue 3 - A-8
ASH News Daily 2016 - Issue 3 - A-9
ASH News Daily 2016 - Issue 3 - A-10
ASH News Daily 2016 - Issue 3 - A-11
ASH News Daily 2016 - Issue 3 - A-12
ASH News Daily 2016 - Issue 3 - A-13
ASH News Daily 2016 - Issue 3 - A-14
ASH News Daily 2016 - Issue 3 - A-15
ASH News Daily 2016 - Issue 3 - A-16
ASH News Daily 2016 - Issue 3 - A-17
ASH News Daily 2016 - Issue 3 - A-18
ASH News Daily 2016 - Issue 3 - A-19
ASH News Daily 2016 - Issue 3 - A-20
ASH News Daily 2016 - Issue 3 - A-21
ASH News Daily 2016 - Issue 3 - A-22
ASH News Daily 2016 - Issue 3 - A-23
ASH News Daily 2016 - Issue 3 - A-24
ASH News Daily 2016 - Issue 3 - A-25
ASH News Daily 2016 - Issue 3 - A-26
ASH News Daily 2016 - Issue 3 - B-1
ASH News Daily 2016 - Issue 3 - B-2
ASH News Daily 2016 - Issue 3 - B-3
ASH News Daily 2016 - Issue 3 - B-4
ASH News Daily 2016 - Issue 3 - B-5
ASH News Daily 2016 - Issue 3 - B-6
ASH News Daily 2016 - Issue 3 - B-7
ASH News Daily 2016 - Issue 3 - B-8
ASH News Daily 2016 - Issue 3 - B-9
ASH News Daily 2016 - Issue 3 - B-10
ASH News Daily 2016 - Issue 3 - B-11
ASH News Daily 2016 - Issue 3 - B-12
ASH News Daily 2016 - Issue 3 - B-13
ASH News Daily 2016 - Issue 3 - B-14
ASH News Daily 2016 - Issue 3 - B-15
ASH News Daily 2016 - Issue 3 - B-16
ASH News Daily 2016 - Issue 3 - B-17
ASH News Daily 2016 - Issue 3 - B-18
ASH News Daily 2016 - Issue 3 - B-19
ASH News Daily 2016 - Issue 3 - B-20
ASH News Daily 2016 - Issue 3 - B-21
ASH News Daily 2016 - Issue 3 - B-22
ASH News Daily 2016 - Issue 3 - B-23
ASH News Daily 2016 - Issue 3 - B-24
ASH News Daily 2016 - Issue 3 - B-25
ASH News Daily 2016 - Issue 3 - B-26
ASH News Daily 2016 - Issue 3 - B-27
ASH News Daily 2016 - Issue 3 - B-28
ASH News Daily 2016 - Issue 3 - B-29
ASH News Daily 2016 - Issue 3 - B-30
ASH News Daily 2016 - Issue 3 - B-31
ASH News Daily 2016 - Issue 3 - B-32
ASH News Daily 2016 - Issue 3 - B-33
ASH News Daily 2016 - Issue 3 - B-34
ASH News Daily 2016 - Issue 3 - B-35
ASH News Daily 2016 - Issue 3 - B-36
ASH News Daily 2016 - Issue 3 - B-37
ASH News Daily 2016 - Issue 3 - B-38
ASH News Daily 2016 - Issue 3 - B-39
ASH News Daily 2016 - Issue 3 - B-40
ASH News Daily 2016 - Issue 3 - B-41
ASH News Daily 2016 - Issue 3 - B-42
ASH News Daily 2016 - Issue 3 - B-43
ASH News Daily 2016 - Issue 3 - B-44
ASH News Daily 2016 - Issue 3 - B-45
ASH News Daily 2016 - Issue 3 - B-46
ASH News Daily 2016 - Issue 3 - B-47
ASH News Daily 2016 - Issue 3 - B-48
ASH News Daily 2016 - Issue 3 - C-1
ASH News Daily 2016 - Issue 3 - C-2
ASH News Daily 2016 - Issue 3 - C-3
ASH News Daily 2016 - Issue 3 - C-4
ASH News Daily 2016 - Issue 3 - C-5
ASH News Daily 2016 - Issue 3 - C-6
ASH News Daily 2016 - Issue 3 - C-7
ASH News Daily 2016 - Issue 3 - C-8
ASH News Daily 2016 - Issue 3 - C-9
ASH News Daily 2016 - Issue 3 - C-10
ASH News Daily 2016 - Issue 3 - C-11
ASH News Daily 2016 - Issue 3 - C-12
ASH News Daily 2016 - Issue 3 - C-13
ASH News Daily 2016 - Issue 3 - C-14
ASH News Daily 2016 - Issue 3 - C-15
ASH News Daily 2016 - Issue 3 - C-16
ASH News Daily 2016 - Issue 3 - C-17
ASH News Daily 2016 - Issue 3 - C-18
ASH News Daily 2016 - Issue 3 - C-19
ASH News Daily 2016 - Issue 3 - C-20
ASH News Daily 2016 - Issue 3 - C-21
ASH News Daily 2016 - Issue 3 - C-22
ASH News Daily 2016 - Issue 3 - C-23
ASH News Daily 2016 - Issue 3 - C-24
ASH News Daily 2016 - Issue 3 - C-25
ASH News Daily 2016 - Issue 3 - C-26
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