Multiple Sclerosis - A Practical Guide to Rehabilitation - 7

A Practical Guide to Rehabilitation
in
A PRACTICAL GUIDE TO IDIOPATHIC

MULTIPLE SCLEROSIS

Table 2: Disease Modifying Therapies for MS15
Approval

Dose & Route of
Administration

Interferon (IFN) β-1b
(Betaseron®)

1993

250 mcg, SC, QOD

IFNβ-1a (Avonex®)

1996

30 mcg, IM, QW

IFNβ-1a (Rebif®)

2002

22 mcg or 44 mcg,
SC, TIW

IFNβ-1b (Extavia®)

2009

250 mcg, SC, QOD

Pegylated IFNβ-1a
(Plegridy™)

2014

125 mcg SC every
14 days

Glatiramer acetate
(Copaxone®)

1996

20 mg, SC, QD

Glatiramer acetate
(Copaxone®)

2014

40 mg, SC, TIW

Glatiramer acetate
(Glatopa™)

2015

20 mg, SC QD

Treatment

Mechanism of Action

Injection
Enhancement of suppressor
T-cell activity, reduction of
proinflammatory cytokine
production, down regulation of
antigen presentation, inhibition
of lymphocyte trafficking into
the CNS

Immunomodulatory;
preferential differentiation of
Th2 cells; and inhibition of
antigen-specific T-cell activation

Infusion
Mitoxantrone
(Novantrone®)

2000

12 mg/m2, IV,
every 3 months

DNA topoisomerase II inhibitor
suppresses proliferation of T- and
B-cells, macrophages

Natalizumab (Tysabri®)

2004

300 mg, IV,
every 4 weeks

Inhibition of α4β1-integrin
mediated adhesion of leukocytes
to VCAM-1 on vascular endothelial cells at the blood brain
barrier, which prevents leukocyte
migration into the brain

Alemtuzumab
(Lemtrada™)

2014

12 mg/day, IV for
5 days; then 12 mg/day
for 3 days 12 months
after the 1st
treatment course

Ocrelizumab (Ocrevus®)

2017

Loading dose, 300 mg
IV x 2, separated over
two weeks, then 600 mg
IV q6 months

Introduction

Anti-CD20 B-cell depletion

7



Multiple Sclerosis - A Practical Guide to Rehabilitation

Table of Contents for the Digital Edition of Multiple Sclerosis - A Practical Guide to Rehabilitation

Contents
Multiple Sclerosis - A Practical Guide to Rehabilitation - Contents
Multiple Sclerosis - A Practical Guide to Rehabilitation - Cover2
Multiple Sclerosis - A Practical Guide to Rehabilitation - 1
Multiple Sclerosis - A Practical Guide to Rehabilitation - 2
Multiple Sclerosis - A Practical Guide to Rehabilitation - 3
Multiple Sclerosis - A Practical Guide to Rehabilitation - 4
Multiple Sclerosis - A Practical Guide to Rehabilitation - 5
Multiple Sclerosis - A Practical Guide to Rehabilitation - 6
Multiple Sclerosis - A Practical Guide to Rehabilitation - 7
Multiple Sclerosis - A Practical Guide to Rehabilitation - 8
Multiple Sclerosis - A Practical Guide to Rehabilitation - 9
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Multiple Sclerosis - A Practical Guide to Rehabilitation - 18
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Multiple Sclerosis - A Practical Guide to Rehabilitation - 65
Multiple Sclerosis - A Practical Guide to Rehabilitation - Cover3
Multiple Sclerosis - A Practical Guide to Rehabilitation - Cover4
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