Isoplexis_July2021_AcceleratingDevelopmentCurativeMedicines - 16

ACCELERATING THE DEVELOPMENT OF CURATIVE MEDICINES WITH FUNCTIONAL IMMUNE PROFILING
IsoPlexis' Immune Profiling
Accelerates Pre-Clinical Animal
Models and Development Timelines
I
soPlexis accelerates pre-clinical and clinical trials
with panels for mouse, non-human primate,
and human. Several recent studies across cancer
immunology and vaccine development, including
the study published in Molecular Therapy, have used
IsoPlexis' unique solutions for mouse models. In a
study by Parisi et al. published in Nature Communications,
researchers used the IsoPlexis platform to show
mechanistic upregulation of NK cells after a novel
agonist therapy, corresponding with persistence in
16 | GENengnews.com
solid tumors in a mouse model. IsoPlexis' single-cell
secretome technology was used to profile translational
insights between early-stage development of
combination PEG-IL2 with ACT therapy. In response
to PEG-IL2, researchers saw upregulated polyfunctionality
in mouse immune cells, which correlated
with increases of proliferation, homing, and antitumor
T cell persistence in vivo.7
Similarly, a study by Li et al., published in Gastroenterology,
used the Single-Cell Secretome technology
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http://www.GENengnews.com

Isoplexis_July2021_AcceleratingDevelopmentCurativeMedicines

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Isoplexis_July2021_AcceleratingDevelopmentCurativeMedicines - Contents
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