Isoplexis_July2021_AcceleratingDevelopmentCurativeMedicines - 5

ACCELERATING THE DEVELOPMENT OF CURATIVE MEDICINES WITH FUNCTIONAL IMMUNE PROFILING
Analysis of Dynamic Immune
Processes Fills Gaps in Understanding
of Severe COVID-19 Pathogenesis
I
n a recent publication in Immunity, researchers
Szabo, et al. used IsoPlexis' low volume highly
multiplexed bulk proteomics solution, CodePlex,
to investigate the role of airway and plasma immune
cells in the pathogenesis of severe COVID-19. Some
patients with SARS-CoV-2 develop severe respiratory
disease, which is marked by lung infiltrates and low
oxygen saturation, and can result in acute respiratory
distress syndrome (ARDS) and death. Several studies
into immune responses to respiratory viruses have
focused on the lungs, where the production of proinflammatory
cytokines can lead to damage.
Tissue-resident memory T cells (TRMs) are the
predominant T cell subset in adult lungs throughout
many decades of life, suggesting they play a
critical role in protecting the lungs from respiratory
GENengnews.com | 5
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Isoplexis_July2021_AcceleratingDevelopmentCurativeMedicines

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Isoplexis_July2021_AcceleratingDevelopmentCurativeMedicines - Contents
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