Sartorius_May21_NeutAntiMakingTheir - 23

NEUTRALIZING ANTIBODIES MAKING THEIR MARK IN NEXT WAVE OF BIOLOGICS

the influenza virus that are critical to

their pre-existing immunity may make

its structure or function do not change,

them susceptible to infection or increase

remaining familiar to our immune system.

the severity of their influenza symptoms

Researchers now understand that

if their antibodies are targeting 'bad' or

specific structural and functional parts

non-neutralizing viral sites, " said co-first

of the influenza virus that do not change

author and immunology postdoctoral fellow

are better for antibodies to target than

Jenna Guthmiller, PhD.

others. Antibodies that bind to one of

By contrast, vaccination largely induces

these neutralizing sites are able to prevent

neutralizing and protective antibodies, old

infection, while antibodies that target

and new, highlighting the importance of

non-neutralizing sites often cannot. Scientists

receiving the seasonal influenza vaccine.

believe a person's age, history of exposure to

" This study provides a major framework

the influenza virus, and type of exposure-

for understanding how pre-existing

either through infection or vaccination-

immunity shapes protective antibody

all shape whether their immune system

responses to influenza in humans, "

antibodies target neutralizing or

said Patrick Wilson, PhD, a professor of

non-neutralizing sites on a virus.

immunology and lead author of the study.

In the study, scientists sought to

" We need more studies to determine

address a major knowledge gap: Which

whether the targeting of specific

conserved viral sites are preferentially

neutralizing and non-neutralizing viral sites

targeted following natural infection

directly impacts a person's likelihood of

versus vaccination in people, and how

becoming ill. "

does pre-existing immunity play a role in

The researchers are now examining how

shaping the landscape of neutralizing and

early exposure to the influenza virus in

non-neutralizing antibodies?

children shapes their immune response later

" For people who have caught the flu,

in life as a follow-up to this work. n

GENengnews.com

| 23


http://www.GENengnews.com

Sartorius_May21_NeutAntiMakingTheir

Table of Contents for the Digital Edition of Sartorius_May21_NeutAntiMakingTheir

Contents
Sartorius_May21_NeutAntiMakingTheir - 1
Sartorius_May21_NeutAntiMakingTheir - 2
Sartorius_May21_NeutAntiMakingTheir - 3
Sartorius_May21_NeutAntiMakingTheir - Contents
Sartorius_May21_NeutAntiMakingTheir - 5
Sartorius_May21_NeutAntiMakingTheir - 6
Sartorius_May21_NeutAntiMakingTheir - 7
Sartorius_May21_NeutAntiMakingTheir - 8
Sartorius_May21_NeutAntiMakingTheir - 9
Sartorius_May21_NeutAntiMakingTheir - 10
Sartorius_May21_NeutAntiMakingTheir - 11
Sartorius_May21_NeutAntiMakingTheir - 12
Sartorius_May21_NeutAntiMakingTheir - 13
Sartorius_May21_NeutAntiMakingTheir - 14
Sartorius_May21_NeutAntiMakingTheir - 15
Sartorius_May21_NeutAntiMakingTheir - 16
Sartorius_May21_NeutAntiMakingTheir - 17
Sartorius_May21_NeutAntiMakingTheir - 18
Sartorius_May21_NeutAntiMakingTheir - 19
Sartorius_May21_NeutAntiMakingTheir - 20
Sartorius_May21_NeutAntiMakingTheir - 21
Sartorius_May21_NeutAntiMakingTheir - 22
Sartorius_May21_NeutAntiMakingTheir - 23
Sartorius_May21_NeutAntiMakingTheir - 24
Sartorius_May21_NeutAntiMakingTheir - 25
Sartorius_May21_NeutAntiMakingTheir - 26
Sartorius_May21_NeutAntiMakingTheir - 27
Sartorius_May21_NeutAntiMakingTheir - 28
Sartorius_May21_NeutAntiMakingTheir - 29
Sartorius_May21_NeutAntiMakingTheir - 30
Sartorius_May21_NeutAntiMakingTheir - 31
Sartorius_May21_NeutAntiMakingTheir - 32
Sartorius_May21_NeutAntiMakingTheir - 33
Sartorius_May21_NeutAntiMakingTheir - 34
Sartorius_May21_NeutAntiMakingTheir - 35
Sartorius_May21_NeutAntiMakingTheir - 36
Sartorius_May21_NeutAntiMakingTheir - 37
Sartorius_May21_NeutAntiMakingTheir - 38
Sartorius_May21_NeutAntiMakingTheir - 39
Sartorius_May21_NeutAntiMakingTheir - 40
Sartorius_May21_NeutAntiMakingTheir - 41
Sartorius_May21_NeutAntiMakingTheir - 42
https://www.nxtbookmedia.com