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NEUTRALIZING ANTIBODIES MAKING THEIR MARK IN NEXT WAVE OF BIOLOGICS

Cover: Ktsdesign / Science Photo Library / Getty Images

The authors found that the B.1.1.7

to neutralization by antibodies to the

variant was resistant to neutralization by

N-terminal domain, the B.1.351 variant

monoclonal antibodies that target the

was found to be resistant to a group of

N-terminal domain of the spike protein and

monoclonal antibodies that is currently used

was relatively resistant to some antibodies

in therapies that target the receptor-binding

that target the receptor-binding domain.

motif of the spike protein, which was

However, it was not resistant to plasma from

primarily attributed to the E484K mutation.

patients who had recovered from COVID-19

The neutralizing activity of plasma from

and sera from individuals who were

patients who had recovered from COVID-19

vaccinated, and the authors suggest that

and sera from people who had been

this variant will not have a marked impact

vaccinated was reduced by approximately

on current therapies or vaccines.

9- and 10-12-fold, respectively, against this

However, in addition to resistance

variant.

GENengnews.com

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Sartorius_May21_NeutAntiMakingTheir

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