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NEUTRALIZING ANTIBODIES MAKING THEIR MARK IN NEXT WAVE OF BIOLOGICS

Synthetic Nanobodies, " Sybodies, "
Found That Neutralize SARS-CoV-2

I

nterrupting the interaction between the

synthetic library, known as sybodies, that target

spike protein on the SARS-CoV-2 virus and

the receptor-binding domain (RBD) of the

its receptor on host cells, ACE2, has become

SARS-CoV-2 Spike protein.

the key target of COVID-19 therapeutics.

This work is published in Nature

Therapeutic neutralizing antibodies achieve this,

Communications in a paper titled, " Selection,

constituting a potential treatment. However,

biophysical, and structural analysis of synthetic

antibody production is traditionally a somewhat

nanobodies that effectively neutralize

slow and expensive process. Now, a German

SARS-CoV-2. "

group of researchers reports the rapid isolation
and characterization of nanobodies from a

To enable the virus to hook onto the cell
surface, the spike protein binds ACE2 using

GENengnews.com

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