Sartorius_May21_NeutAntiMakingTheir - 30

NEUTRALIZING ANTIBODIES MAKING THEIR MARK IN NEXT WAVE OF BIOLOGICS

Abstract
Since COVID-19 was first discovered in late 2019, millions of people have been infected, and hundreds
of thousands of deaths reported so far. Controlling the outbreak and disease progression in infected
persons requires the development of vaccines and therapeutics in accelerated timelines. In this article,
we review a few selected studies on SARS CoV 2 structural biology, host receptor recognition properties,
cross-reactivity with SARS CoV and MERS CoV neutralization antibodies, and several workflows aimed at
developing neutralization antibodies and therapeutics and how Octet® label-free platforms are utilized to
accelerate experimental timelines.

Octet Bio-Layer Interferometry
Systems: Advancing Development of
Coronavirus Vaccine and Therapeutics
®

NILSHAD SALIM

Introduction

chances of success. Since the COVID-19 genome

The World Health Organization declared the

sequence was first shared in January 2020,

new COVID-19 outbreak as a pandemic on

Octet® system data has been featured in several

the 11th of March 2020. Millions of people have

breakthrough publications related to coronavirus

been infected worldwide with the virus, and

biology, vaccine and antiviral therapeutic

hundreds of thousands of deaths reported so

development.
Octet® BLI platforms are helping accelerate

far. The rapidly evolving epidemiology of the
pandemic and absence of a licensed therapeutic

SARS CoV-2 research by providing scientists:

or vaccine for the disease has accelerated the

*	

High-throughput kinetic interaction analysis

need to develop an intervention. At the heart of

solutions to select and characterize antigenic

the search for a vaccine are modern biochemical

targets, vaccine and therapeutic candidates fast

and analytical technologies that can be deployed

*	

Fast and flexible platform for antibody

for the rapid screening of the many potential

epitope characterization and coverage

candidates to determine those with the best

determination

30 |

GENengnews.com


http://www.GENengnews.com

Sartorius_May21_NeutAntiMakingTheir

Table of Contents for the Digital Edition of Sartorius_May21_NeutAntiMakingTheir

Contents
Sartorius_May21_NeutAntiMakingTheir - 1
Sartorius_May21_NeutAntiMakingTheir - 2
Sartorius_May21_NeutAntiMakingTheir - 3
Sartorius_May21_NeutAntiMakingTheir - Contents
Sartorius_May21_NeutAntiMakingTheir - 5
Sartorius_May21_NeutAntiMakingTheir - 6
Sartorius_May21_NeutAntiMakingTheir - 7
Sartorius_May21_NeutAntiMakingTheir - 8
Sartorius_May21_NeutAntiMakingTheir - 9
Sartorius_May21_NeutAntiMakingTheir - 10
Sartorius_May21_NeutAntiMakingTheir - 11
Sartorius_May21_NeutAntiMakingTheir - 12
Sartorius_May21_NeutAntiMakingTheir - 13
Sartorius_May21_NeutAntiMakingTheir - 14
Sartorius_May21_NeutAntiMakingTheir - 15
Sartorius_May21_NeutAntiMakingTheir - 16
Sartorius_May21_NeutAntiMakingTheir - 17
Sartorius_May21_NeutAntiMakingTheir - 18
Sartorius_May21_NeutAntiMakingTheir - 19
Sartorius_May21_NeutAntiMakingTheir - 20
Sartorius_May21_NeutAntiMakingTheir - 21
Sartorius_May21_NeutAntiMakingTheir - 22
Sartorius_May21_NeutAntiMakingTheir - 23
Sartorius_May21_NeutAntiMakingTheir - 24
Sartorius_May21_NeutAntiMakingTheir - 25
Sartorius_May21_NeutAntiMakingTheir - 26
Sartorius_May21_NeutAntiMakingTheir - 27
Sartorius_May21_NeutAntiMakingTheir - 28
Sartorius_May21_NeutAntiMakingTheir - 29
Sartorius_May21_NeutAntiMakingTheir - 30
Sartorius_May21_NeutAntiMakingTheir - 31
Sartorius_May21_NeutAntiMakingTheir - 32
Sartorius_May21_NeutAntiMakingTheir - 33
Sartorius_May21_NeutAntiMakingTheir - 34
Sartorius_May21_NeutAntiMakingTheir - 35
Sartorius_May21_NeutAntiMakingTheir - 36
Sartorius_May21_NeutAntiMakingTheir - 37
Sartorius_May21_NeutAntiMakingTheir - 38
Sartorius_May21_NeutAntiMakingTheir - 39
Sartorius_May21_NeutAntiMakingTheir - 40
Sartorius_May21_NeutAntiMakingTheir - 41
Sartorius_May21_NeutAntiMakingTheir - 42
https://www.nxtbookmedia.com