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NEUTRALIZING ANTIBODIES MAKING THEIR MARK IN NEXT WAVE OF BIOLOGICS

TABLE OF CONTENTS

Neutralizing Antibodies Making
Their Mark in Next Wave of Biologics
05 		 Coronavirus-Neutralizing Human Antibody
Discovered
Antibody Internalization Reagent Principles
Outside cell:
pH ~7.4

08 		 Antibody Internalization: Advanced Flow
Cytometry and Live-Cell Analysis Give Rich
Insights During Antibody Profiling

Inside cell:
pH ~7.0-7.2

Antibody
Mix Antibody
20 		 Antibody
Response
to Flu ShapedAdd
bylabeled test antibody
Internalization
Internalization
to cells and read on iQue3
Reagent Immunity
Reagent with
(iQue3 VBR, BR, BR HD)
Pre-Existing
test antibody

24		 SARS-CoV-2 Variants B.1.351 and B.1.1.7
Show Resistance to Neutralizing Antibodies

27 		 Synthetic Nanobodies, " Sybodies, " Found
That Neutralize SARS-CoV-2

30		 Octet® Bio-Layer Interferometry Systems:
Advancing Development of Coronavirus
Vaccine and Therapeutics

Cover: KTSdesign / Science Photo Library / Getty Images
© GEN Publishing * April 2021

4|

GENengnews.com

Early
endosome:
pH ~6.3

Late
endosome:
pH ~5.5

Lysosome:
pH ~4.7


http://www.GENengnews.com

Sartorius_May21_NeutAntiMakingTheir

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