Sartorius_May21_NeutAntiMakingTheir - 6

Coronavirus-Neutralizing Human Antibody Discovered

PhD, co-lead author on the study, Academy

strain caused ~8000 infections, with a lethality of

Professor of Cell Biology, Erasmus Medical

10%. There are currently no approved targeted

Center, Rotterdam and Founding CSO at Harbour

therapeutics are available for COVID-19, the

BioMed. " The antibody used in this work is 'fully

disease caused by SARS-CoV-2.

human,' allowing development to proceed more

Monoclonal antibodies targeting " vulnerable

rapidly and reducing the potential for immune-

sites " on viral surface proteins are increasingly

related side effects. "

recognized as a promising class of drugs
against infectious diseases, and have shown

" Using this collection of
SARS-CoV antibodies,
we identified an antibody
that also neutralizes
infection of SARS-CoV-2
in cultured cells. "
	

-	Frank Grosveld, PhD,
		 Erasmus Medical Center, Rotterdam
Grosveld and colleagues report on the

therapeutic efficacy for a number of viruses,
the authors wrote. Coronavirus-neutralizing
antibodies primarily target the trimeric spike (S)
glycoproteins on the coronavirus surface that
mediate entry into host cells. The S protein has
two functional subunits. The S1 subunit, which
is composed of four core domains, S1A through
to S1D, mediates attachment to the host cell. The
S2 domain mediates fusion of the viral and cell
membranes.
The spike proteins of SARS-CoV-2 and

antibody in Nature Communications, in a paper

SARS-CoV share 77.5% identical amino acid

titled, " A human monoclonal antibody blocking

sequence, and are structurally very similar, the

SARS-CoV-2 infection. "

investigators continued. They commonly bind the

Both SARS-CoV-2 and the SARS-CoV virus that

human angiotensin converting enzyme 2 (ACE2)

emerged in 2002, belong to the Sarbecovirus

protein as the host receptor. " Potent neutralizing

subgenus of the Betacoronavirus family of

antibodies often target the receptor interaction

coronaviruses. The two viruses crossed species

site in S1, disabling receptor interactions, " the

barriers from an animal reservoir, and can cause

authors continued.

life-threatening respiratory illness in humans. By

For their reported antibody discovery effort,

May 4th, 2020 there were more than 3.4 million

Grosveld and colleagues built on work that the

confirmed cases of SARS-CoV-2 worldwide,

groups had carried out on antibodies targeting

and in excess of 230,000 deaths. The SARS-CoV

SARS-CoV, explained co-lead author Berend-Jan

6|

GENengnews.com


http://www.GENengnews.com

Sartorius_May21_NeutAntiMakingTheir

Table of Contents for the Digital Edition of Sartorius_May21_NeutAntiMakingTheir

Contents
Sartorius_May21_NeutAntiMakingTheir - 1
Sartorius_May21_NeutAntiMakingTheir - 2
Sartorius_May21_NeutAntiMakingTheir - 3
Sartorius_May21_NeutAntiMakingTheir - Contents
Sartorius_May21_NeutAntiMakingTheir - 5
Sartorius_May21_NeutAntiMakingTheir - 6
Sartorius_May21_NeutAntiMakingTheir - 7
Sartorius_May21_NeutAntiMakingTheir - 8
Sartorius_May21_NeutAntiMakingTheir - 9
Sartorius_May21_NeutAntiMakingTheir - 10
Sartorius_May21_NeutAntiMakingTheir - 11
Sartorius_May21_NeutAntiMakingTheir - 12
Sartorius_May21_NeutAntiMakingTheir - 13
Sartorius_May21_NeutAntiMakingTheir - 14
Sartorius_May21_NeutAntiMakingTheir - 15
Sartorius_May21_NeutAntiMakingTheir - 16
Sartorius_May21_NeutAntiMakingTheir - 17
Sartorius_May21_NeutAntiMakingTheir - 18
Sartorius_May21_NeutAntiMakingTheir - 19
Sartorius_May21_NeutAntiMakingTheir - 20
Sartorius_May21_NeutAntiMakingTheir - 21
Sartorius_May21_NeutAntiMakingTheir - 22
Sartorius_May21_NeutAntiMakingTheir - 23
Sartorius_May21_NeutAntiMakingTheir - 24
Sartorius_May21_NeutAntiMakingTheir - 25
Sartorius_May21_NeutAntiMakingTheir - 26
Sartorius_May21_NeutAntiMakingTheir - 27
Sartorius_May21_NeutAntiMakingTheir - 28
Sartorius_May21_NeutAntiMakingTheir - 29
Sartorius_May21_NeutAntiMakingTheir - 30
Sartorius_May21_NeutAntiMakingTheir - 31
Sartorius_May21_NeutAntiMakingTheir - 32
Sartorius_May21_NeutAntiMakingTheir - 33
Sartorius_May21_NeutAntiMakingTheir - 34
Sartorius_May21_NeutAntiMakingTheir - 35
Sartorius_May21_NeutAntiMakingTheir - 36
Sartorius_May21_NeutAntiMakingTheir - 37
Sartorius_May21_NeutAntiMakingTheir - 38
Sartorius_May21_NeutAntiMakingTheir - 39
Sartorius_May21_NeutAntiMakingTheir - 40
Sartorius_May21_NeutAntiMakingTheir - 41
Sartorius_May21_NeutAntiMakingTheir - 42
https://www.nxtbookmedia.com