Sartorius_May21_NeutAntiMakingTheir - 7

NEUTRALIZING ANTIBODIES MAKING THEIR MARK IN NEXT WAVE OF BIOLOGICS

Bosch, Associate Professor, research leader at

neutralization by RBD-targeting antibodies

Utrecht University. " Using this collection of

have been reported including spike inactivation

SARS-CoV antibodies, we identified an antibody

through antibody-induced destabilization of its

that also neutralizes infection of SARS-CoV-2 in

prefusion structure, which may also apply for

cultured cells. " The human antibody identified,

47D11, " the team noted.

47D11, was generated using Harbour BioMed's
H2L2 transgenic mouse technology.
47D11 was shown to bind to cells expressing

" In conclusion, this is the first report of a
(human) monoclonal antibody that neutralizes
SARS-CoV-2, " they concluded. " This antibody

the full-length spike proteins of both SARS-CoV

will be useful for development of antigen

and SARS-CoV-2, and potently inhibited viral

detection tests and serological assays targeting

infection of cultured cells. Tests showed that

SARS-CoV-2 ... this antibody-either alone or

the antibody targeted the S1B receptor-binding

in combination-offers the potential to prevent

domain (RBD) of the spike proteins of both

and/or treat COVID-19, and possibly also other

viruses. The fact that the antibody is cross-reactive

future emerging diseases in humans caused by

indicates that it likely targets the conserved

viruses from the Sarbecovirus subgenus. "

core structure of the S1B RBD, the investigators

" This is groundbreaking research, " said

suggested. " Such a neutralizing antibody has

Jingsong Wang, PhD, founder, Chairman

potential to alter the course of infection in the

& Chief Executive Officer of HBM. " Much

infected host, support virus clearance or protect

more work is needed to assess whether this

an uninfected individual that is exposed to the

antibody can protect or reduce the severity

virus, " Bosch stated.

of disease in humans. We expect to advance

Interestingly, the team's results suggested that

development of the antibody with partners.

47D11 neutralizes SARS-CoV and SARS-CoV-2

We believe our technology can contribute

through " a yet unknown mechanism " that is

to addressing this most urgent public health

different from receptor-binding interference.

need and we are pursuing several other

" Alternative mechanisms of coronavirus

research avenues. " n

GENengnews.com

|7


http://www.GENengnews.com

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