Cisbio eBook - 12

Targeting Protein-Protein Interactions Yields

Getty Images / theasis

A Cornucopia
of New Therapies

Advanced tools, assays make inroads toward finding molecules
to thwart protein-protein interactions in a variety of diseases
Caroline Seydel

U

ntil recently, protein-protein interactions
(PPIs) have been considered essentially
"undruggable," in part because of the presumed
featurelessness of the interface between
protein partners. But PPIs play a huge role in
cellular processes, and understanding them
could reveal new ways to attack cancer, neurodegenerative disease, and infections. Over
the last decade or so, new tools, libraries, and
assays have emerged that make it more attractive to join the hunt for small molecule therapeutics that target protein-protein interactions.
12 | GENengnews.com

"For a long time, it's been thought they're these
big, bland interfaces," says Andrew Voter, a PhD
student in biochemistry at the University of
Wisconsin-Madison. "Imagine a baseball in a
catcher's mitt, maybe, and you'd have to block
the whole baseball, was the thinking." Recently,
however, scientists are starting to appreciate
that there's a wide variety of complexity among
the interfaces.
"The idea that they're a single class is kind of
silly," notes Michelle Arkin, PhD, co-director

ADDITIONAL CONTENT

Guide
The ultimate guide to
develop and optimize
PPI assays

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Cisbio eBook

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Contents
Cisbio eBook - 1
Cisbio eBook - 2
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Cisbio eBook - Contents
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