Cisbio eBook - 5
Some specific interactions are now at the center
of drug discovery research
Lessons from the Past and Current Directions
Richard A. Stein, M.D., Ph.D.
P
rotein-protein interactions, the basis of
cellular structure and function, are critical for
virtually all pathways underlying development,
health, and disease. The past few decades have
witnessed major advances in the ability to interrogate and exploit interactions between proteins
and, in parallel, the field has developed better
capabilities to target them therapeutically. As
a result, certain interactions that were initially
viewed as intractable have emerged more
recently at the forefront of drug discovery efforts.
"For a long time, many people believed that
5 | GENengnews.com
membrane-spanning segments are inert anchors
that simply insert proteins into membranes
or hold proteins there," says Daniel DiMaio,
MD, PhD, Waldemar Von Zedtwitz Professor of
Genetics, professor of molecular biophysics and
biochemistry, professor of therapeutic radiology
at Yale University, and deputy director of the Yale
Cancer Center.
It is estimated that up to one third of eukaryotic proteins, including many drug targets, are
embedded into either the plasma membrane or
ADDITIONAL CONTENT
Infographics
A short history of
protein-protein
interactions
See Now
Getty Images / Science Photo Library / PASIEKA
Protein-Protein
Interactions
http://learn.cisbio.com/lp/infographics-a-brief-history-of-protein-protein-interaction
http://learn.cisbio.com/lp/infographics-a-brief-history-of-protein-protein-interaction
http://www.GENengnews.com
Cisbio eBook
Table of Contents for the Digital Edition of Cisbio eBook
Contents
Cisbio eBook - 1
Cisbio eBook - 2
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Cisbio eBook - Contents
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