Clinical OMICs - Issue 3 - (Page 3)

Innovative Practices, Actionable Results Behold the pathology report of the future: guide to customized care and treatment monitoring FUTURE CANCER CARE: ANTICIPATING "PANOMICS" WITH BIOINFORMATICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Will multiple omics readouts be needed for treatment decisions? BRINGING INFORMED INTERPRETATION TO VEXING VARIANTS . . . . . . . . .12 Groups hammer out guidelines for assessing pathogenicity of gene mutations. WHAT TO LOOK FOR IN A CLINICAL NEXT-GENERATION SEQUENCER . . . . . .17 Although there is only one FDA-cleared NGS platform on the market now, by the end of the year, several competing products are expected to be available. Regular Features INNOVATOR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .20 PROMOTING WELLNESS AND DEMYSTIFYING DISEASE: THE 100K PROJECT Leroy Hood envisions a wellness industry that could exceed in market cap the "disease industry" in the next 10-15 years. SNAPSHOT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .24 CIRCULATING BIOMARKERS FOR LIQUID BIOPSIES Already showing promise as highly effective diagnostic tools, circulating biomarkers can easily be obtained from blood, urine, cerebrospinal fluids and other biological fluids. CASE STUDY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .26 A GLOBAL PHOSPHORYLATION ASSAY A retrospective analysis was performed to highlight the utility of SysQuant to support drug selection in the clinic. NEWS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 NEW PRODUCTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .15 BEST CLINICAL APPS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .31 www.clinicalomics.com May 15, 2014 Clinical OMICs 3 https://www.youtube.com/channel/UCXBPPWZv--Ne4NfAUHcc8hg https://twitter.com/ClinicalOMICs http://www.clinicalomics.com

Table of Contents for the Digital Edition of Clinical OMICs - Issue 3

Contents

Clinical OMICs - Issue 3