Clinical OMICs - Issue 3 - (Page 8)
Future Cancer Care:
Patricia Fitzpatrick Dimond, Ph.D.
n 2009 Mark Boguski and colleagues published a paper entitled
"Customized care 2020: how medical sequencing and network biology will enable personalized medicine." In the paper the authors
described a model incorporating these pathways, annotation of disease networks and drug targets, and simulation of therapeutic interventions with virtual drugs or with combinations of them.
The pathology report of the future, the authors said, will provide precision
diagnoses that are at the core of personalized medicine and will be an interactive software tool for clinical teams to design a customized care regimen and
monitor its efficacy during treatment.
Beyond cancer, noted Zhu et al. in their 2007 paper in PLOS Computational
Biology, molecular dissection of diseases such as obesity and diabetes will
require a systematic approach to show how genes interact with one another,
and with genetic and environmental factors.
With respect to cancer, completion of the human genome sequence has led
to a postgenomic era that includes detailed exploration of the DNA sequence
(the genome), DNA sequences that are transcribed into mRNA (the transcriptome), and the translated and post-translationally modified
PATRICIA FITZPATRICK DIMOND, Ph.D.
protein sequences (the proteome). The new paradigm in canhas been a long-time contributor to GEN cer, researchers say, encompasses analysis of entire gene and
and currently serves as the publication's
protein sets to identify a "reasonable" drug target. Multiple
Technical Editor. She is also president of
experimental and data analysis methodologies are being
BioInsight Communications. During her
career in the biotechnology industry,
used to achieve this goal, and bioinformatics support is an
she was VP of strategic development
essential component of this research effort.
and corporate communications at Coley
As a discipline, according to Abeloff's Clinical Oncology,
Pharmaceutical Group (now Pfizer),
where she developed and managed the company's
"bioinformatics sits at the interface where biology and mediinvestor relations and communications programs.
cine meet a confluence of quantitative sciences, including
computer science, mathematics, and statistics." While we are
Clinical OMICs May 15, 2014
Table of Contents for the Digital Edition of Clinical OMICs - Issue 3
Clinical OMICs - Issue 3