# Clinical OMICs - Volume 3, Issue 5 - (Page 3)

Molecular Diagnostics in Personalized Medicine Swollen data reservoirs can become stagnant pools, or they can drive clinical innovation- it all depends on how the information is channeled. BIG DATA'S BIG IMPLICATIONS FOR CANCER TREATMENTS . . . . 6 Data mining unearths pathways and networks that yield clinical gold. THE EPIGENETIC INSIGHTS OF RNA-SEQ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .10 The use of RNA-Seq to investigate RNA species and how they can regulate gene expression has enormous applicability toward the development of clinical diagnostics. PAVING THE ROAD FOR CLINICAL BIOMARKERS . . . . . . . . . . . . . 14 Where trackless terrain once challenged biomarker development, clearer paths are emerging, speeding progress toward companion diagnostics, multiplex assays, and protocols for managing chronic (but unsettled) conditions. Regular Features INNOVATOR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .21 Thirty Years of Transforming Healthcare Genetic Alliance promotes engagement of individuals, families, and communities. CLINICAL GENOMICS UPDATE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .24 Sequencing the Snark: Comparison of Whole-Genome Sequencing Strategies for the Detection of Somatic Mutations in Cancer The rapid advancement of NGS in clinical diagnostics underscores the need for more assay standardization. Cover: NCI Center for Cancer Research / Steve Mabon,Tom Misteli Above (top): Massachussetts General Hospital (MGH) Cancer Center, Harvard Medical School; (bottom): iStock / Ljupco / Clinical OMICs www.clinicalomics.com NEWS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 NEW PRODUCTS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .20 MEETING ROUNDUP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .30 May 2016 Clinical OMICs 3 https://www.youtube.com/channel/UCXBPPWZv--Ne4NfAUHcc8hg https://twitter.com/ClinicalOMICs http://www.clinicalomics.com

Contents

# Clinical OMICs - Volume 3, Issue 5

https://www.nxtbook.com/nxtbooks/gen/clinical_omics_vol3iss9
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