Clinical OMICs - Volume 3, Issue 9 - 27

In Vitro Diagnostic System The ARIES® M1 System is a fully integrated, sample to answer platform for performing real-time PCR assays. The system has recently received FDA clearance and CE-IVD marking, with a design that is targeted for lower throughput clinical labs. The ARIES M1 System is designed to aid satellite clinical laboratories in taking advantage of the same benefits as the higher throughput ARIES System, with features such as an intuitive system interface, STAT or batch testing, and true walkaway capability. The system extracts, amplifies, and detects nucleic acid targets from a variety of sample types. Once the cassettes are loaded onto the instrument, results are generated without additional technical intervention. The system can process up to six different samples, and one to six assays, at a time. Luminex Controls for Molecular Diagnostics Testing Amplichek™ I quality controls represent the second in a series of infectious disease controls introduced for molecular diagnostic testing this year. Amplichek I is an independent, multi-analyte quality control for the assessment of HIV-1, Hepatitis B (HBV), and Hepatitis C (HCV) nucleic acid tests that can help mitigate the limitations of manufacturer controls. Unlike some controls that are optimized for specific systems, Amplichek I can help reduce the risk associated with reporting inaccurate patient results by monitoring the performance of the complete analytical process and detecting lot-to-lot variation of assay reagents. This product was recently issued a 510(k) clearance from the U.S. Food and Drug Administration. Bio-Rad CRISPR gRNA Lentivector Cloning Kits The new CRISPR gRNA Lentivector Cloning Kits provide scientists with a targeted and precise genomic gene editing methodology. The new kit provides the standalone premade Cas9 expression lentivirus, and the gRNA lentivector cloning kits from which you can construct your desired target gRNA lentivectors. Applying both Cas9 lentivirus and gRNA lentivirus allows you to achieve the target knockOut or modification (knockIn) when a donor DNA is also applied. The new kits enable rapid, precisely directional cloning of your DNA duplex encoded gRNA structure at efficiencies of greater than 95%. The lentivector included in kit encodes an antibiotic marker or a dual marker (a fluorescent-antibiotic fusion marker) allowing generation of stable cell lines for long-term gRNA expression. There are two promoters available: U6 and an optional inducible H1 promoter. Amsbio ChIP-Seq Spike-In Normalization Strategy ChIP-Seq Spike-in corrects for technical variation that occurs as a result of the multistep ChIP/ChIP-Seq protocols. The addition of two key reagents, Spike-in Chromatin and Spike-in Antibody to standard ChIP reactions provides a means to track sample variation and normalize the data appropriately. The need to normalize whole-genome datasets has become evident in the RNA-Seq community, where spike-in is becoming common practice. The new system is easily implemented and universally applicable to any ChIP experimental set-up. The ChIP Spike-in Chromatin and Antibody reagents and protocol are available for purchase together as well as being incorporated into a variety of Active Motif's end-to-end ChIP-Seq services. Active Motif www.clinicalomics.com September 2016 Clinical OMICs 27 http://www.luminexcorp.com/ http://www.amsbio.com/ http://www.bio-rad.com/ http://www.activemotif.com/ http://www.clinicalomics.com

Table of Contents for the Digital Edition of Clinical OMICs - Volume 3, Issue 9