Clinical OMICs - Volume 3, Issue 9 - 8
Marking the
Sweet Spot for
Immunotherapies
Jeffrey S. Buguliskis, Ph.D.
T
he principle underlying molecular diagnostics is simple-devise a
methodology that quickly detects an altered state through the analysis of a biological marker. With that philosophy in mind, companies go
to great lengths to develop sophisticated equipment that will accurately
measure either a single or collection of biomarkers that are known indicators of disease. Yet, with advances continually making technology smaller,
faster, and cheaper, a molecular diagnostic device is only as good as the
biological entity that it seeks to identify.
In many ways, nucleic acids seem like ideal candidates for researchers to use as
markers of disease pathology. Indeed, there are a fair number of molecular diagnostic tests that exploit the subtle genetic variations (SNPs, copy number variations,
etc.,) that exist between abnormal and unaffected genomes. Yet, protein samples
offer a significantly greater degree of differentiated information content than their
nucleic acid counterparts. Moreover, there are a considerable number of protein
molecules that are secreted by cells which are often sought after as diagnostic
markers due to their relative ease of harvestJEFFREY S. BUGULISKIS, Ph.D., ing. In contrast, the methodology required to
isolated nucleic acid markers can be elaborate
is Technical Editor of GEN
and time-consuming.
and Clinical OMICs.
Adding to their versatility, many protein bio(jbuguliskis@genengnews.com)
markers have the additional advantage of not
8
Clinical OMICs September 2016
www.clinicalomics.com
http://www.clinicalomics.com
Table of Contents for the Digital Edition of Clinical OMICs - Volume 3, Issue 9
Contents
Clinical OMICs - Volume 3, Issue 9 - Cover1
Clinical OMICs - Volume 3, Issue 9 - Cover2
Clinical OMICs - Volume 3, Issue 9 - Contents
Clinical OMICs - Volume 3, Issue 9 - 4
Clinical OMICs - Volume 3, Issue 9 - 5
Clinical OMICs - Volume 3, Issue 9 - 6
Clinical OMICs - Volume 3, Issue 9 - 7
Clinical OMICs - Volume 3, Issue 9 - 8
Clinical OMICs - Volume 3, Issue 9 - 9
Clinical OMICs - Volume 3, Issue 9 - 10
Clinical OMICs - Volume 3, Issue 9 - 11
Clinical OMICs - Volume 3, Issue 9 - 12
Clinical OMICs - Volume 3, Issue 9 - 13
Clinical OMICs - Volume 3, Issue 9 - 14
Clinical OMICs - Volume 3, Issue 9 - 15
Clinical OMICs - Volume 3, Issue 9 - 16
Clinical OMICs - Volume 3, Issue 9 - 17
Clinical OMICs - Volume 3, Issue 9 - 18
Clinical OMICs - Volume 3, Issue 9 - 19
Clinical OMICs - Volume 3, Issue 9 - 20
Clinical OMICs - Volume 3, Issue 9 - 21
Clinical OMICs - Volume 3, Issue 9 - 22
Clinical OMICs - Volume 3, Issue 9 - 23
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Clinical OMICs - Volume 3, Issue 9 - 25
Clinical OMICs - Volume 3, Issue 9 - 26
Clinical OMICs - Volume 3, Issue 9 - 27
Clinical OMICs - Volume 3, Issue 9 - 28
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Clinical OMICs - Volume 3, Issue 9 - 30
Clinical OMICs - Volume 3, Issue 9 - 31
Clinical OMICs - Volume 3, Issue 9 - 32
Clinical OMICs - Volume 3, Issue 9 - 33
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