Antibody Screening Solutions Made Easy - 31

Antibody Screening Solutions Made Easy * New Methods Improve Ab Engineering

The company has engineered mRNAs to prevent immune reactions of
the body. "The final step in purification of therapeutic mRNAs eliminates
double-stranded RNA, remaining RNA/DNA hybrids, and impurities,"
notes Dr. Kreiter. "These precautions lead to a non-immunogenic mRNA
that does not provoke an immune response against the mRNA itself or
the encoded protein."
Preliminary results show that mRNA produced a superior therapeutic
outcome when compared to the protein itself, by providing a sustained
response. Additionally, by employing mRNA instead of protein,
production time for making mRNA is much shorter than that of proteins,
with completion of the process done in weeks rather than months, notes
Dr. Kreiter, explaining that delivery of therapies via mRNA is a viable
alternative to protein-based injections.
"I believe that cancer treatments will be multimodal, not just a combination of small molecule compounds, but a combination of small molecules,
either proteins or mRNA, and vaccines," he says. n

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Antibody Screening Solutions Made Easy

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