Antibody Screening Solutions Made Easy - 32

Antibody Factory
in a Dish
Wendy Wolfson

32

| GENengnews.com

When stimulated by an infection or vaccine, the
immune system's B-cells respond to antigens by
signaling through their surface B cell receptors
(BCRs), setting off a cascade that spurs proliferation and secretion of antibody-producing
plasma cells. "Plasma cells are the antibody
factories," Batista told GEN.
But generating antibodies in vitro from patient
blood is difficult because the B cells need to be
primed with an additional signal such as CD40
or TLR and to be dosed with different interleukin

ADDITIONAL CONTENT

Application Note
Better Hybridoma Screening
Learn how Intellicyt's high throughput suspension
cell screening platform enables simultaneous assessment
of antigen binding and cross-reactivity thus reducing
workflow steps and increases productivity while screening
for hybridoma libraries.

Download Now

Andrew Brookes / Getty Images

A

novel in vitro vaccine booster strategy
could lead to faster production of human
monoclonal antibodies (mAbs) and shorten
vaccine development by speeding evaluation
of antigens, according to researchers. In a paper
published in the Journal of Experimental Medicine on July 24, 2017, an international group of
researchers led by Facundo Batista, PhD, associate
director of the Ragon Institute of Massachusetts
General Hospital, Harvard, and MIT, described a
method to stimulate human memory B cells to
produce antigen-specific antibodies.

https://intellicyt.com/resources/better-hybridoma-screening/ http://www.GENengnews.com

Antibody Screening Solutions Made Easy

Table of Contents for the Digital Edition of Antibody Screening Solutions Made Easy