IsoPlexis eBook - 9

The Polyfunctional Strength Index:
From Concept to Solution

T

he success of cell-based immunotherapies is transforming
precision medicine, even though the full clinical potential
of these therapies has yet to be exploited. Cell therapies are
highly complex, heterogeneous, edited living drugs making their
behavior tricky to characterize, predict and optimize.

for cancer, autoimmune and infectious diseases.

Unlike a small molecule or antibody that always has the same
structure, each time an autologous cell therapy is developed the
starting material comes from a different patient, making it virtually
impossible to reproducibly develop an identical "drug". Having the
ability to drive better outcomes by profiling the complete function
of each cell would be a significant advantage for bioengineers-
a challenge the IsoPlexis single-cell proteomic system has been
designed to address.

Single Cell Proteomics and the Immune System

In a recent Genetic Engineering & Biotechnology News webinar,
Jonathan Chen, co-inventor and Director of New Collaborations
at IsoPlexis, and James R. Heath, Ph.D., President of the Institute for
Systems Biology and IsoPlexis' co-founder, discussed the history of
the technology and how it has begun to redefine what is possible
by stratifying patient response to novel immunotherapy regimens

9

| GENengnews.com

To view the on demand webinar, visit:
https://www.genengnews.com/resources/webinars/better-bydesign-single-cell-characterization-for-enhanced-cell-therapies/.

Over the past decade, Dr. Heath's research team has developed
single-cell characterization methods that led to the formation of the
IsoPlexis technology. The Polyfunctional Strength Index (PSIā„¢) has
progressed from an initial report of an interesting metric to a compelling demonstration of the detailed resolution of effective therapies
and responses.
The PSI is defined as the percentage of polyfunctional single cells in a
sample that secretes two or more proteins, multiplied by the average
signal intensity of the secreted proteins from individual functional
groups from each cell. Each cell's strength, across one thousand or
more cells, is aggregated and simplified to provide a comprehensible
visualization of the potent cell subsets and the cytokine types that
drive them.

Additional Content
WEBINAR

Better by Design:
Single-Cell Characterization
for Enhanced Cell Therapies
View It Now


https://www.genengnews.com/resources/webinars/better-by-design-single-cell-characterization-for-enha https://www.genengnews.com/resources/webinars/better-by-design-single-cell-characterization-for-enha https://www.genengnews.com/resources/webinars/better-by-design-single-cell-characterization-for-enhanced-cell-therapies/ http://www.GENengnews.com

IsoPlexis eBook

Table of Contents for the Digital Edition of IsoPlexis eBook

Contents
IsoPlexis eBook - 1
IsoPlexis eBook - 2
IsoPlexis eBook - Contents
IsoPlexis eBook - 4
IsoPlexis eBook - 5
IsoPlexis eBook - 6
IsoPlexis eBook - 7
IsoPlexis eBook - 8
IsoPlexis eBook - 9
IsoPlexis eBook - 10
IsoPlexis eBook - 11
IsoPlexis eBook - 12
IsoPlexis eBook - 13
IsoPlexis eBook - 14
IsoPlexis eBook - 15
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