Jax Labs eBook - 15

Lessons from
sequencing "Eve" C57BL/6J
Are you using the B6 substrain corresponding
to the latest Reference Genome Sequence?

A

team of JAX researchers recently published "The Genome of C57BL/6J 'Eve,' the
Mother of the Laboratory Mouse Genome Reference Strain," which is currently
distributed by The Jackson Laboratory. The B6J strain is maintained via a Genetic
Stability Program with periodic reintroduction of cryorecovered mice derived from a
single breeder pair. The genomic sequence of Eve more accurately represents the
genome of today's C57BL/6J mice compared to the first release of the mouse reference
genome (GRCm38) 20 years ago.
THE POINT OF USING MICE FOR BIOMEDICAL RESEARCH
The mouse is an essential model organism for biomedical research. Decades of
research analyzing and manipulating the mouse genome have translated into a better
understanding of human physiology and diseases. Genomic approaches have the
ability to connect phenotypes with genotypes for a wide variety of traits and to use
the resulting molecular insights to develop new ways to cure and prevent disease.
The laboratory mouse occupies a central place in this vision as a well-characterized
organism for modeling human disease states.
The availability of the full mouse genome sequence greatly advanced both the

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A D D I T I O N A L CO N T E N T

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Jax Labs eBook

Table of Contents for the Digital Edition of Jax Labs eBook

Contents
Jax Labs eBook - 1
Jax Labs eBook - 2
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Jax Labs eBook - Contents
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