Jax Labs eBook - 16

IMPACTFUL SOLUTIONS CREATE INNOVATIVE SCIENCE

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type and the pace of discovery. Mus musculus, a
species of mouse, has been one of the five key model
organisms sequenced since the beginning of the
Human Genome Project. The sequence of the mouse
genome is a key informational tool for understanding
the contents of the human genome and a key
experimental tool for biomedical research. The initial
sequence of the mouse genome reported in 2002 was
a first step in this intellectual endeavor (Waterston
et al., 2002) and allowed comparative analysis to
examine the similarities and differences between the
human and mouse genomes.
Isogenic laboratory mouse strains enhance
reproducibility because individual animals are
genetically identical. For the most widely used
isogenic strain, C57BL/6, there exists a wealth of
genetic, phenotypic, and genomic data, including
a high-quality reference genome that evolved with
time (GRCm38.p6 being the latest release). However,
traditional inbreeding practices create a genetic
bottleneck: every generation, between 10 and 30 new
mutations pop up and are passed on to offspring.
Unfortunately, most of these mutations are not easy
to spot until researchers are investigating specific
traits (Reardon, 2017). It is now very clear that
different suppliers of B6 mice have inadvertently
16 | GENengnews.com


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Jax Labs eBook

Table of Contents for the Digital Edition of Jax Labs eBook

Contents
Jax Labs eBook - 1
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Jax Labs eBook - Contents
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