Jax Labs eBook - 25

Center: Getty Images, CreativeNature_nl; Right: Getty Images, ktsimage

Using Aged Mice to Test New Targets:
Investigating stroke therapeutic targets
using JAX aged C57BL/6J mice

T

he brain is a highly complex organ comprised of a large number of cells and
molecules, each with its own unique function. Diseases that affect the central
nervous system (CNS), such as brain injury or stroke, not only kill vulnerable
neurons, but often severely disrupt cell-cell signaling in the surviving cells (Guo et al.,
2018; George and Steinberg, 2015). Discovering therapeutics to halt the domino effect
that includes loss of cells and often portions of the brain, such as those observed
in stroke patients, has been a slow process. One of the challenges in researching
stroke and developing
A stroke, which affects millions of patients worldwide, primarily
therapeutics, like many
involves the complex circuitry of the brain. In a recent study by
other types of human

Bastian and colleagues, the authors examined whether inhibition
of a specific protein kinase would protect white matter from
ischemic stroke-induced injury. Using aged C57BL/6J mice from
JAX, the authors were able to test their therapeutic successfully.

diseases/conditions, is mimicking the cellular interactions in
an in vivo platform.
Including aged mice in these types of studies presents
several advantages over other models, in that they
can be genetically modified to examine the molecular
pathophysiology. Furthermore, aged mice are a vital model
25 | GENengnews.com

A D D I T I O N A L CO N T E N T

Unravel the drug discovery
path with JAX G O THER E



http://www.jax.org/neurobiology http://www.GENengnews.com

Jax Labs eBook

Table of Contents for the Digital Edition of Jax Labs eBook

Contents
Jax Labs eBook - 1
Jax Labs eBook - 2
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Jax Labs eBook - Contents
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