Jax Labs eBook - 26

IMPACTFUL SOLUTIONS CREATE INNOVATIVE SCIENCE

as stroke generally affects the elderly.
Aged C57BL/6J mice-both males and
females-up to 78 weeks of age which is
equivalent to about 56 human years, are
available from JAX for use in studies, such
as those for stroke.

perspectives, utilizing an in vivo model that
mimics a targeted feature is more likely to
yield translationally-relevant data.
A recent study by Bastian and
colleagues (Bastian et al., 2018) examined
whether protein kinase inhibition

mice at 12 and 20 months.
As white matter becomes increasingly
susceptible to injury with age, the authors
examined the optic nerves from 12 and
20 month old C57BL/6J mice. Following
oxygen glucose deprivation in these mice,

would protect white matter function
and structure, and therefore serve as a
therapeutic target for stroke patients and
other neurodegenerative conditions. The
authors used JAX aged C57BL/6J male

the authors observed that compound
action potentials exhibited minimal
recovery. However, inhibiting CK2 kinase
prevented a complete loss of compound
action potential during oxygen glucose

A stroke is the result of a sudden
disruption in the blood supply to the
brain. Various mechanisms, including
excitotoxicity, free radical release, protein
misfolding, and inflammatory changes can
cause neural injury or death. White matter
injury, in conjunction with astrocyte death
or injury, also contributes to cerebral
damage, which can manifest as a loss of
speech, motor function, and/or memory
(Marin and Carmichael, 2018; George and
Steinberg, 2015; Balkaya et al., 2013).
This catastrophic event for both patients
and families is the fourth largest cause of
death in the United States and the leading
medical cause of disability worldwide
(Ritzel et al., 2018; Fluri et al., 2015).
From drug development and research
26 | GENengnews.com

Getty Images, stockdevil

USING AGED MICE IN STROKE RESEARCH



https://www.ncbi.nlm.nih.gov/pubmed/?term=29944965 http://www.GENengnews.com

Jax Labs eBook

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