Jax Labs eBook - 27


deprivation and improved the compound
action potential area recovery during
post-oxygen glucose deprivation.
To investigate whether inhibition of
CDK5 and AKT promoted axon function
in optic nerves of 12-month-old mice,
the authors administered roscovitine
or MK-2206, inhibitors of AKT, at
pre-, during, and post-oxygen glucose
deprivation. They observed that roscovitine
given prior to oxygen glucose deprivation
improved compound action potential area,
whereas MK-2206 treatment preserved
compound action potential area during
oxygen glucose deprivation and promoted
axonal recovery following oxygen glucose
deprivation. These observations indicate
that CK2 inhibition improves axon function
recovery following an ischemic episode,
and CDK5 and AKT are effector molecules
that mediate these protective effects.
In the study by Bastian and colleagues,
they investigated the use of kinase
27 | GENengnews.com

inhibitors to treat ischemic strokerelated neuronal injuries. Using aged
mice, which is an appropriate model for
conducting stroke research, they observed
post-ischemic protection following
administration of their therapeutic. As the
authors note, this therapeutic may result
in successful translation into clinical trials.
For nearly 90 years, JAX-a pioneer
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Balkaya, M., et al. (2013). "Assessing post-stroke behavior in
mouse models of focal ischemia." J Cereb Blood Flow Metab
33(3): 330-338.
Bastian, C., et al. (2018). "CK2 inhibition confers functional
protection to young and aging axons against ischemia
by differentially regulating the CDK5 and AKT signaling
pathways." Neurobiol Dis.
Fluri, F., et al. (2015). "Animal models of ischemic stroke and
their application in clinical research." Drug Des Devel Ther
9: 3445-3454.
George PM, Steinberg GK., 2015. Novel Stroke Therapeutics:
Unraveling Stroke Pathophysiology and Its Impact on Clinical
Treatments. Neuron 87(2): 297-309. [PMID: 26182415]
Guo D, Deng W, Xing C., et al., 2018. Effects of aging,
hypertension and diabetes on the mouse brain and
heart vasculomes. Neurobiol Dis. Jul. DOI: 10.1016/j.
nbd.2018.07.021. [PMID: 30031157]
Marin MA, Carmichael ST., 2018. Stroke in CNS White Matter:
Models and Mechanisms. Neurosci Lett. Aug. DOI: 10.1016/j.
neulet.2018.07.039. [PMID: 30098384]
Ritzel RM, Lai YJ, Crapser JD., et al., 2018. Aging alters
the immunological response to ischemic stroke. Acta
Neuropathol. May. DOI: 10.1007/s00401-018-1859-2. [PMID:

https://www.jax.org/jax-mice-and-services/find-and-order-jax-mice/most-popular-jax-mice-strains/aged-b6 https://www.jax.org/jax-mice-and-services/in-vivo-pharmacology/neurobiology-services/friedreichs-ataxia-efficacy-studies https://www.jax.org/jax-mice-and-services/customer-support/manuals-posters-and-guides/jmcrs-manuals-guides/booklet-neuro https://www.jax.org/jax-mice-and-services/customer-support/manuals-posters-and-guides/jmcrs-manuals-guides/aged-b6-whitepaper https://www.jax.org/mouse-search https://www.jax.org/strain/010830 http://www.GENengnews.com

Jax Labs eBook

Table of Contents for the Digital Edition of Jax Labs eBook

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