Jax Labs eBook - 34

IMPACTFUL SOLUTIONS CREATE INNOVATIVE SCIENCE | QUICK FACTS

WHICH HUMANIZED FCRN MODEL IS RIGHT FOR MY THERAPEUTIC?
When half-life measurements are compared for clinically approved therapeutic IgGs, the
values in humanized FcRn mice, particularly for FcRn Tg 32, correlate strikingly well to
human data (Figure 4A).

Figure 4. Belatacept, Ipilimumab, and Pembrolizumab half-life values were measured in FcRn Tg32 (A), FcRn Tg 276
(B), and wildtype mice (C) and compared to known human data. FcRn Tg32 generated the most clinically predictive data,
while wildtype mice failed to predict human data.

While it shows an intermediate correlation to human data (Figure 4B), the strength
of the FcRn Tg276 model lies in its ability to allow fine distinctions in half-life between
several candidate molecules (Figure 5).
If you are concerned your therapeutic may generate anti-therapeutic antibodies
in the mouse host, immunodeficient versions of these humanized FcRn models are
available. Importantly, the immunodeficiency in these models does not alter the half-life
correlation data demonstrated in the original immunocompetent versions.
34 | GENengnews.com

Figure 5. FcRn Tg276 allows distinction between
several variant therapeutic IgGs. Variant 1 shows
longer half-life compared to Variant 2, which is
more easily discerned using the FcRn Tg276 model
compared to the FcRn Tg32 model.


http://www.GENengnews.com

Jax Labs eBook

Table of Contents for the Digital Edition of Jax Labs eBook

Contents
Jax Labs eBook - 1
Jax Labs eBook - 2
Jax Labs eBook - 3
Jax Labs eBook - Contents
Jax Labs eBook - 5
Jax Labs eBook - 6
Jax Labs eBook - 7
Jax Labs eBook - 8
Jax Labs eBook - 9
Jax Labs eBook - 10
Jax Labs eBook - 11
Jax Labs eBook - 12
Jax Labs eBook - 13
Jax Labs eBook - 14
Jax Labs eBook - 15
Jax Labs eBook - 16
Jax Labs eBook - 17
Jax Labs eBook - 18
Jax Labs eBook - 19
Jax Labs eBook - 20
Jax Labs eBook - 21
Jax Labs eBook - 22
Jax Labs eBook - 23
Jax Labs eBook - 24
Jax Labs eBook - 25
Jax Labs eBook - 26
Jax Labs eBook - 27
Jax Labs eBook - 28
Jax Labs eBook - 29
Jax Labs eBook - 30
Jax Labs eBook - 31
Jax Labs eBook - 32
Jax Labs eBook - 33
Jax Labs eBook - 34
Jax Labs eBook - 35
Jax Labs eBook - 36
https://www.nxtbookmedia.com