Jax Labs eBook - 35

IMPACTFUL SOLUTIONS CREATE INNOVATIVE SCIENCE | QUICK FACTS

WHO PROVIDES SERVICES TO TEST HALF-LIFE
OF MY THERAPEUTIC FOR ME?
The humanized FcRn mouse models were created and published at The Jackson
Laboratory by Derry Roopenian, PhD. As part of JAX's mission to empower the global
biomedical community to discover solutions for human disease, we offer Therapeutic
Antibody Half-Life Evaluation Services using these unique and clinically relevant
humanized FcRn mouse models to researchers developing novel IgG, Fc-, or
albumin-based therapeutics. Contact the JAX Technical Information Scientist Team
to learn more. nn

RECOMMENDED RESOURCES:
Therapeutic Antibody Evaluation Services
Blog: Revealing antibody half-life stability using FcRn
mouse models from JAX
Webinar: De-Risk Therapeutic Antibody Drug
Development Using Humanized FcRn Mice
FcRn Portfolio

REFERENCES:
Roopenian DC; Christianson GJ; Sproule TJ; Brown
AC; Akilesh S; Jung N; Petkova S; Avanessian L;
Choi EY; Shaffer DJ; Eden PA; Anderson CL. 2003.
The MHC class I-like IgG receptor controls perinatal
IgG transport, IgG homeostasis, and fate of IgG-Fccoupled drugs. J Immunol 170(7):3528-33 [PMID
12646614]
Roopenian DC, Akilesh S. 2007. FcRn: the neonatal
Fc receptor comes of age. Nat Rev Immunol. 7(9):
715-25. [PMID: 17703228]
Chaudhury C; Mehnaz S; Robinson JM; Hayton WL;
Pearl DK; Roopenian DC; Anderson CL. 2003. The
major histocompatibility complex-related Fc receptor
for IgG (FcRn) binds albumin and prolongs its
lifespan. J Exp Med 197(3):315-22 [PMID 12566415]
Kamath AV. 2016. Translational pharmacokinetics and
pharmacodynamics of monoclonal antibodies. Drug
Discov Today Technol. 21-22: 75-83. [PMID: 27978991]

Getty Images, poba

Weiner GJJ. 2015. Building better monoclonal antibodybased therapeutics. Nat Rev Cancer. 15(6); 361-70.
[PMID: PMC4491443]

35 | GENengnews.com


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Jax Labs eBook

Table of Contents for the Digital Edition of Jax Labs eBook

Contents
Jax Labs eBook - 1
Jax Labs eBook - 2
Jax Labs eBook - 3
Jax Labs eBook - Contents
Jax Labs eBook - 5
Jax Labs eBook - 6
Jax Labs eBook - 7
Jax Labs eBook - 8
Jax Labs eBook - 9
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