Optimize, Adapt and Overcome - 36

GEN ROUNDUP

How to Improve
Cell-Line Productivity
A Productive Cell Line Needs More Than a Good
Pedigree, It Needs Proper Care and Feeding

To help our readers maintain their equilibrium,
GEN has consulted with the steadiest cell-line
experts available. They explain how to keep
cell-line productivity high-and stable.
36

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GEN If the goal of CHO cell-

line development is to improve
productivity and/or protein quality,
which factor, clone selection or media
feed, has been most responsible for
these improvements and why?
Dr. Pankiewicz
Development of CHO stable cell lines expressing high amounts of high-quality recombinant
protein is the first step in efficient production of
therapeutic proteins. Historically, the main focus
in cell-line development has been on generating

ADDITIONAL CONTENT
iStock/Reptile8488

eveloping a highly productive cell line is a
balancing act. Due weight must be given
to various factors, particularly clone selection
and media feed. And yet more finesse will be
required if bioprocessors are to get the most out
of the newer cell lines, many of which are bound
to embody the most subtle shifts gene-editing
technologies such as CRISPR can allow.

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Select High-value Cell Lines Like a Pro
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Optimize, Adapt and Overcome

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