Sartorius eBook - 10

THE FUTURE OF DRUG DISCOVERY: LIVE 3D CELL ANALYSIS

3D "Squeeze" Helps
Adult Cells Become Stem Cells

A

convergence of physical and chemical

January 11 in the journal Nature Materials, in

factors can turn adult cells into stem

an article entitled, "Defined three-dimensional

cells more efficiently than chemical

microenvironments boost induction of

factors alone. The physical factors that can help

pluripotency." The article describes how the

induce pluripotency amount to a kind of cellular

scientists modulated microenvironmental

swaddling, the formation of a three-dimensional

stiffness, degradability, and biochemical

embrace that can be loosened or tightened as

composition to identify a previously unknown

needed.

role for "biophysical effectors" in the generation of

That adult cells might need cuddling should

induced pluripotent stem cells (iPSCs).

come as no surprise, even though cell cultures

"We find that the physical cell confinement

are typically two dimensional. Cells in the body

imposed by the 3D microenvironment boosts

exist in a three-dimensional world.

reprogramming through an accelerated

To explore the possibilities of three-dimensional

mesenchymal-to-epithelial transition

cultures, scientists based at Ecole Polytechnique

and increased epigenetic remodeling,"

Fédérale de Lausanne have been engineering

wrote the authors. "We conclude that 3D

three-dimensional extracellular matrices-gels, in

microenvironmental signals act synergistically

short. These scientists, led by Matthias Lutolf, Ph.D.,

with reprogramming transcription factors to

report that they have developed a gel that boosts

increase somatic plasticity."

the ability of normal cells to revert into stem cells
by simply "squeezing" them.
The details of the scientists' work appeared
10 |

GENengnews.com

Essentially, the researchers discovered that
they could reprogram the cells faster and more
efficiently than current methods by simply


http://www.GENengnews.com

Sartorius eBook

Table of Contents for the Digital Edition of Sartorius eBook

Contents
Sartorius eBook - 1
Sartorius eBook - 2
Sartorius eBook - 3
Sartorius eBook - Contents
Sartorius eBook - 5
Sartorius eBook - 6
Sartorius eBook - 7
Sartorius eBook - 8
Sartorius eBook - 9
Sartorius eBook - 10
Sartorius eBook - 11
Sartorius eBook - 12
Sartorius eBook - 13
Sartorius eBook - 14
Sartorius eBook - 15
Sartorius eBook - 16
Sartorius eBook - 17
Sartorius eBook - 18
Sartorius eBook - 19
Sartorius eBook - 20
Sartorius eBook - 21
Sartorius eBook - 22
Sartorius eBook - 23
Sartorius eBook - 24
Sartorius eBook - 25
Sartorius eBook - 26
Sartorius eBook - 27
Sartorius eBook - 28
Sartorius eBook - 29
Sartorius eBook - 30
Sartorius eBook - 31
Sartorius eBook - 32
Sartorius eBook - 33
Sartorius eBook - 34
Sartorius eBook - 35
Sartorius eBook - 36
Sartorius eBook - 37
Sartorius eBook - 38
Sartorius eBook - 39
Sartorius eBook - 40
Sartorius eBook - 41
Sartorius eBook - 42
Sartorius eBook - 43
Sartorius eBook - 44
Sartorius eBook - 45
Sartorius eBook - 46
https://www.nxtbookmedia.com